Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot?

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Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot?

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dc.contributor.author Massaro, Joseph M.
dc.contributor.author Vasan, Ramachandran S.
dc.contributor.author O'Donnel, Christopher J.
dc.contributor.author Porter, Stacy Ann
dc.contributor.author Hoffmann, Udo
dc.contributor.author Fox, Caroline
dc.date.accessioned 2012-02-14T00:45:11Z
dc.date.issued 2009
dc.identifier.citation Porter, Stacy A., Joseph M. Massaro, Udo Hoffmann, Ramachandran S. Vasan, Christopher J. O'Donnel, and Caroline S. Fox. 2009. Abdominal subcutaneous adipose tissue: A protective fat depot? Diabetes Care 32, no. 6: 1068-1075. en_US
dc.identifier.issn 0149-5992 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160860
dc.description.abstract OBJECTIVE: Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored. RESEARCH DESIGN AND METHODS: Participants from the Framingham Heart Study (n = 3,001, 48.5% women) were stratified by visceral adipose tissue (VAT) into sex-specific tertiles. Within these tertiles, age-adjusted abdominal subcutaneous adipose tissue (SAT) tertiles were examined in relation to cardiometabolic risk factors. RESULTS: In the lowest VAT tertile, risk factor prevalence was low, although systolic blood pressure in women and rates of high triglycerides, impaired fasting glucose, hypertension, and the metabolic syndrome in men increased with increasing SAT tertile (all P < 0.04). In contrast, in the top VAT tertile, lower triglycerides were observed in men with increasing SAT (64.4% high triglycerides in SAT tertile 1 vs. 52.7% in SAT tertile 3, P = 0.03). Similar observations were made for women, although results were not statistically significant (50.6% high triglycerides in SAT tertile 1 vs. 41.0% in tertile 3, P = 0.10). Results in the highest VAT tertile were notable for a lack of increase in the prevalence of low HDL in men and women and in rates of impaired fasting glucose in men with increasing subcutaneous fat, despite sizable differences in BMI across SAT tertiles (27.1 to 36.3 kg/m\(^2\) [women]; 28.1 to 35.7 kg/m\(^2\) [men]). CONCLUSIONS: Although adiposity increases the absolute risk of metabolic and cardiovascular disease, abdominal subcutaneous fat is not associated with a linear increase in the prevalence of all risk factors among the obese, most notably, high triglycerides. en_US
dc.language.iso en_US en_US
dc.publisher American Diabetes Association en_US
dc.relation.isversionof doi://10.2337/dc08-2280 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681034/pdf/ en_US
dash.license LAA
dc.title Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot? en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Diabetes Care en_US
dash.depositing.author Hoffmann, Udo
dc.date.available 2012-02-14T00:45:11Z
dash.affiliation.other HMS^Stipendees - Enrichment Programs Stip en_US
dash.affiliation.other HMS^Radiology-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US

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