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dc.contributor.authorThadhani, Ravi Ishwar
dc.contributor.authorPowe, Camille Elise
dc.contributor.authorTjoa, May Lee
dc.contributor.authorKhankin, Eliyahu
dc.contributor.authorYe, Jun
dc.contributor.authorEcker, Jeffrey Lawrence
dc.contributor.authorSchneyer, Alan
dc.contributor.authorKarumanchi, Subbian Ananth
dc.date.accessioned2012-02-14T03:21:39Z
dc.date.issued2009
dc.identifier.citationThadhani, Ravi, Camille E. Powe, May Lee Tjoa, Eliyahu Khankin, Jun Ye, Jeffrey Ecker, Alan Schneyer, and S. Ananth Karumanchi. 2010. First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus. Diabetes Care 33(3): 664-669.en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160880
dc.description.abstractObjective: To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent gestational diabetes mellitus (GDM). Research Design and Methods: This was a nested case-control study of subjects enrolled in a prospective cohort of pregnant women with and without GDM (\(\geq\)2 abnormal values on a 100-g glucose tolerance test at ~28 weeks of gestation). We measured FSTL3 levels in serum collected during the first trimester of pregnancy. Logistic regression analyses were used to determine the risk of GDM. Results: Women who developed GDM (n = 37) had lower first-trimester serum levels of FSTL3 compared with women who did not (n = 127) (median 10,789 [interquartile range 7,013-18,939] vs. 30,670 [18,370-55,484] pg/ml, P < 0.001). When subjects were divided into tertiles based on FSTL3 levels, women with the lowest levels demonstrated a marked increase in risk for developing GDM in univariate (odds ratio 11.2 [95% CI 3.6-35.3]) and multivariate (14.0 [4.1-47.9]) analyses. There was a significant negative correlation between first-trimester FSTL3 levels and ~28-week nonfasting glucose levels (r = -0.30, P < 0.001). Conclusions: First-trimester FSTL3 levels are associated with glucose intolerance and GDM later in pregnancy.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi://10.2337/dc09-1745en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827528/pdf/en_US
dash.licenseLAA
dc.subjectcardiovascular and metabolic risken_US
dc.titleFirst-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitusen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetes Careen_US
dash.depositing.authorThadhani, Ravi Ishwar
dc.date.available2012-02-14T03:21:39Z
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherHMS^Obstetrics Gynecology and Repro. Bio. - BIDMCen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dc.identifier.doi10.2337/dc09-1745*
dash.contributor.affiliatedPowe, Camille
dash.contributor.affiliatedThadhani, Ravi
dash.contributor.affiliatedKhankin, Eliyahu
dash.contributor.affiliatedKarumanchi, Subbian
dash.contributor.affiliatedEcker, Jeffrey


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