dc.contributor.author | Thadhani, Ravi Ishwar | |
dc.contributor.author | Powe, Camille Elise | |
dc.contributor.author | Tjoa, May Lee | |
dc.contributor.author | Khankin, Eliyahu | |
dc.contributor.author | Ye, Jun | |
dc.contributor.author | Ecker, Jeffrey Lawrence | |
dc.contributor.author | Schneyer, Alan | |
dc.contributor.author | Karumanchi, Subbian Ananth | |
dc.date.accessioned | 2012-02-14T03:21:39Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Thadhani, Ravi, Camille E. Powe, May Lee Tjoa, Eliyahu Khankin, Jun Ye, Jeffrey Ecker, Alan Schneyer, and S. Ananth Karumanchi. 2010. First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus. Diabetes Care 33(3): 664-669. | en_US |
dc.identifier.issn | 0149-5992 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160880 | |
dc.description.abstract | Objective: To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent gestational diabetes mellitus (GDM). Research Design and Methods: This was a nested case-control study of subjects enrolled in a prospective cohort of pregnant women with and without GDM (\(\geq\)2 abnormal values on a 100-g glucose tolerance test at ~28 weeks of gestation). We measured FSTL3 levels in serum collected during the first trimester of pregnancy. Logistic regression analyses were used to determine the risk of GDM. Results: Women who developed GDM (n = 37) had lower first-trimester serum levels of FSTL3 compared with women who did not (n = 127) (median 10,789 [interquartile range 7,013-18,939] vs. 30,670 [18,370-55,484] pg/ml, P < 0.001). When subjects were divided into tertiles based on FSTL3 levels, women with the lowest levels demonstrated a marked increase in risk for developing GDM in univariate (odds ratio 11.2 [95% CI 3.6-35.3]) and multivariate (14.0 [4.1-47.9]) analyses. There was a significant negative correlation between first-trimester FSTL3 levels and ~28-week nonfasting glucose levels (r = -0.30, P < 0.001). Conclusions: First-trimester FSTL3 levels are associated with glucose intolerance and GDM later in pregnancy. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Diabetes Association | en_US |
dc.relation.isversionof | doi://10.2337/dc09-1745 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827528/pdf/ | en_US |
dash.license | LAA | |
dc.subject | cardiovascular and metabolic risk | en_US |
dc.title | First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Diabetes Care | en_US |
dash.depositing.author | Thadhani, Ravi Ishwar | |
dc.date.available | 2012-02-14T03:21:39Z | |
dash.affiliation.other | HMS^Medicine-Massachusetts General Hospital | en_US |
dash.affiliation.other | HMS^Health Sciences and Technology | en_US |
dash.affiliation.other | HMS^Medicine- Beth Israel-Deaconess | en_US |
dash.affiliation.other | HMS^Obstetrics Gynecology and Repro. Bio. - BIDMC | en_US |
dash.affiliation.other | HMS^Medicine- Beth Israel-Deaconess | en_US |
dc.identifier.doi | 10.2337/dc09-1745 | * |
dash.contributor.affiliated | Powe, Camille | |
dash.contributor.affiliated | Thadhani, Ravi | |
dash.contributor.affiliated | Khankin, Eliyahu | |
dash.contributor.affiliated | Karumanchi, Subbian | |
dash.contributor.affiliated | Ecker, Jeffrey | |