First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus

First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus

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First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus

dc.contributor.author	Tjoa, May Lee
dc.contributor.author	Schneyer, Alan
dc.contributor.author	Thadhani, Ravi Ishwar
dc.contributor.author	Powe, Camille Elise
dc.contributor.author	Khankin, Eliyahu
dc.contributor.author	Ye, Jun
dc.contributor.author	Ecker, Jeffrey Lawrence
dc.contributor.author	Karumanchi, Subbian Ananth
dc.date.accessioned	2012-02-14T03:21:39Z
dc.date.issued	2009
dc.identifier.citation	Thadhani, Ravi, Camille E. Powe, May Lee Tjoa, Eliyahu Khankin, Jun Ye, Jeffrey Ecker, Alan Schneyer, and S. Ananth Karumanchi. 2010. First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus. Diabetes Care 33(3): 664-669.	en_US
dc.identifier.issn	0149-5992	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160880
dc.description.abstract	Objective: To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent gestational diabetes mellitus (GDM). Research Design and Methods: This was a nested case-control study of subjects enrolled in a prospective cohort of pregnant women with and without GDM (\(\geq\)2 abnormal values on a 100-g glucose tolerance test at ~28 weeks of gestation). We measured FSTL3 levels in serum collected during the first trimester of pregnancy. Logistic regression analyses were used to determine the risk of GDM. Results: Women who developed GDM (n = 37) had lower first-trimester serum levels of FSTL3 compared with women who did not (n = 127) (median 10,789 [interquartile range 7,013-18,939] vs. 30,670 [18,370-55,484] pg/ml, P < 0.001). When subjects were divided into tertiles based on FSTL3 levels, women with the lowest levels demonstrated a marked increase in risk for developing GDM in univariate (odds ratio 11.2 [95% CI 3.6-35.3]) and multivariate (14.0 [4.1-47.9]) analyses. There was a significant negative correlation between first-trimester FSTL3 levels and ~28-week nonfasting glucose levels (r = -0.30, P < 0.001). Conclusions: First-trimester FSTL3 levels are associated with glucose intolerance and GDM later in pregnancy.	en_US
dc.language.iso	en_US	en_US
dc.publisher	American Diabetes Association	en_US
dc.relation.isversionof	doi://10.2337/dc09-1745	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827528/pdf/	en_US
dash.license	LAA
dc.subject	cardiovascular and metabolic risk	en_US
dc.title	First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Diabetes Care	en_US
dash.depositing.author	Thadhani, Ravi Ishwar
dc.date.available	2012-02-14T03:21:39Z
dash.affiliation.other	HMS^Medicine-Massachusetts General Hospital	en_US
dash.affiliation.other	HMS^Health Sciences and Technology	en_US
dash.affiliation.other	HMS^Medicine- Beth Israel-Deaconess	en_US
dash.affiliation.other	HMS^Obstetrics Gynecology and Repro. Bio. - BIDMC	en_US
dash.affiliation.other	HMS^Medicine- Beth Israel-Deaconess	en_US