5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

DSpace/Manakin Repository

5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

Citable link to this page

. . . . . .

Title: 5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis
Author: Xu, Yong; Jones, Juli E.; Kohno, Daisuke; Williams, Kevin W.; Choi, Michelle J.; Anderson, Jason G.; Heisler, Lora K.; Zigman, Jeffrey M.; Elmquist, Joel K.; Lee, Charlotte E.; Lowell, Bradford Barr

Note: Order does not necessarily reflect citation order of authors.

Citation: Xu, Yong, Juli E. Jones, Daisuke Kohno, Kevin W. Williams, Charlotte E. Lee, Michelle J. Choi, Jason G. Anderson, et al. 2008. 5-HT\(_{\text{2C}}\)Rs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60(4): 582-589.
Access Status: At the direction of the depositing author this work is not currently accessible through DASH.
Full Text & Related Files:
Abstract: Drugs activating 5-hydroxytryptamine 2C receptors (5-HT\(_{\text{2C}}\)Rs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT\(_{\text{2C}}\)Rs deficiency (2C null) and mice with 5-HT\(_{\text{2C}}\)Rs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). We show that 2C null mice predictably developed hyperphagia, hyperactivity, and obesity and showed attenuated responses to anorexigenic 5-HT drugs. Remarkably, all these deficiencies were normalized in 2C/POMC mice. These results demonstrate that 5-HT\(_{\text{2C}}\)R expression solely in POMC neurons is sufficient to mediate effects of serotoninergic compounds on food intake. The findings also highlight the physiological relevance of the 5-HT\(_{\text{2C}}\)R-melanocortin circuitry in the long-term regulation of energy balance.
Published Version: doi:10.1016/j.neuron.2008.09.033
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631191/pdf/
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8191178

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters