5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis
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5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis
| Title: | 5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis |
| Author: |
Xu, Yong; Jones, Juli E.; Kohno, Daisuke; Williams, Kevin W.; Choi, Michelle J.; Anderson, Jason G.; Heisler, Lora K.; Zigman, Jeffrey M.; Elmquist, Joel K.; Lee, Charlotte E.; Lowell, Bradford Barr
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Xu, Yong, Juli E. Jones, Daisuke Kohno, Kevin W. Williams, Charlotte E. Lee, Michelle J. Choi, Jason G. Anderson, et al. 2008. 5-HT\(_{\text{2C}}\)Rs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60(4): 582-589. |
| Access Status: | At the direction of the depositing author this work is not currently accessible through DASH. |
| Full Text & Related Files: |
2631191.pdf (1.001Mb; PDF) 
|
| Abstract: | Drugs activating 5-hydroxytryptamine 2C receptors (5-HT\(_{\text{2C}}\)Rs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT\(_{\text{2C}}\)Rs deficiency (2C null) and mice with 5-HT\(_{\text{2C}}\)Rs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). We show that 2C null mice predictably developed hyperphagia, hyperactivity, and obesity and showed attenuated responses to anorexigenic 5-HT drugs. Remarkably, all these deficiencies were normalized in 2C/POMC mice. These results demonstrate that 5-HT\(_{\text{2C}}\)R expression solely in POMC neurons is sufficient to mediate effects of serotoninergic compounds on food intake. The findings also highlight the physiological relevance of the 5-HT\(_{\text{2C}}\)R-melanocortin circuitry in the long-term regulation of energy balance. |
| Published Version: | doi:10.1016/j.neuron.2008.09.033 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631191/pdf/ |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8191178 |
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