5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

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5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

dc.contributor.author	Xu, Yong
dc.contributor.author	Jones, Juli E.
dc.contributor.author	Kohno, Daisuke
dc.contributor.author	Williams, Kevin W.
dc.contributor.author	Choi, Michelle J.
dc.contributor.author	Anderson, Jason G.
dc.contributor.author	Heisler, Lora K.
dc.contributor.author	Zigman, Jeffrey M.
dc.contributor.author	Elmquist, Joel K.
dc.contributor.author	Lee, Charlotte E.
dc.contributor.author	Lowell, Bradford Barr
dc.date.accessioned	2012-02-19T23:27:56Z
dc.date.issued	2008
dc.identifier.citation	Xu, Yong, Juli E. Jones, Daisuke Kohno, Kevin W. Williams, Charlotte E. Lee, Michelle J. Choi, Jason G. Anderson, et al. 2008. 5-HT\(_{\text{2C}}\)Rs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60(4): 582-589.	en_US
dc.identifier.issn	0896-6273	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:8191178
dc.description.abstract	Drugs activating 5-hydroxytryptamine 2C receptors (5-HT\(_{\text{2C}}\)Rs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT\(_{\text{2C}}\)Rs deficiency (2C null) and mice with 5-HT\(_{\text{2C}}\)Rs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). We show that 2C null mice predictably developed hyperphagia, hyperactivity, and obesity and showed attenuated responses to anorexigenic 5-HT drugs. Remarkably, all these deficiencies were normalized in 2C/POMC mice. These results demonstrate that 5-HT\(_{\text{2C}}\)R expression solely in POMC neurons is sufficient to mediate effects of serotoninergic compounds on food intake. The findings also highlight the physiological relevance of the 5-HT\(_{\text{2C}}\)R-melanocortin circuitry in the long-term regulation of energy balance.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Cell Press	en_US
dc.relation.isversionof	doi:10.1016/j.neuron.2008.09.033	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631191/pdf/	en_US
dash.license	META_ONLY
dc.subject	humdisease	en_US
dc.subject	molneuro	en_US
dc.subject	signaling	en_US
dc.title	5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Neuron	en_US
dash.depositing.author	Lowell, Bradford Barr
dash.embargo.until	10000-01-01
dash.affiliation.other	HMS^Medicine- Beth Israel-Deaconess	en_US