5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

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5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

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dc.contributor.author Xu, Yong
dc.contributor.author Jones, Juli E.
dc.contributor.author Kohno, Daisuke
dc.contributor.author Williams, Kevin W.
dc.contributor.author Choi, Michelle J.
dc.contributor.author Anderson, Jason G.
dc.contributor.author Heisler, Lora K.
dc.contributor.author Zigman, Jeffrey M.
dc.contributor.author Elmquist, Joel K.
dc.contributor.author Lee, Charlotte E.
dc.contributor.author Lowell, Bradford Barr
dc.date.accessioned 2012-02-19T23:27:56Z
dc.date.issued 2008
dc.identifier.citation Xu, Yong, Juli E. Jones, Daisuke Kohno, Kevin W. Williams, Charlotte E. Lee, Michelle J. Choi, Jason G. Anderson, et al. 2008. 5-HT\(_{\text{2C}}\)Rs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60(4): 582-589. en_US
dc.identifier.issn 0896-6273 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8191178
dc.description.abstract Drugs activating 5-hydroxytryptamine 2C receptors (5-HT\(_{\text{2C}}\)Rs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT\(_{\text{2C}}\)Rs deficiency (2C null) and mice with 5-HT\(_{\text{2C}}\)Rs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). We show that 2C null mice predictably developed hyperphagia, hyperactivity, and obesity and showed attenuated responses to anorexigenic 5-HT drugs. Remarkably, all these deficiencies were normalized in 2C/POMC mice. These results demonstrate that 5-HT\(_{\text{2C}}\)R expression solely in POMC neurons is sufficient to mediate effects of serotoninergic compounds on food intake. The findings also highlight the physiological relevance of the 5-HT\(_{\text{2C}}\)R-melanocortin circuitry in the long-term regulation of energy balance. en_US
dc.language.iso en_US en_US
dc.publisher Cell Press en_US
dc.relation.isversionof doi:10.1016/j.neuron.2008.09.033 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631191/pdf/ en_US
dash.license META_ONLY
dc.subject humdisease en_US
dc.subject molneuro en_US
dc.subject signaling en_US
dc.title 5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Neuron en_US
dash.depositing.author Lowell, Bradford Barr
dash.embargo.until 10000-01-01
dash.affiliation.other HMS^Medicine- Beth Israel-Deaconess en_US

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