Glutamate Transporter: An Unexpected Target for Some Antibiotics
| Title: | Glutamate Transporter: An Unexpected Target for Some Antibiotics |
| Author: | Mao, Jianren |
| Citation: | Mao, Jianren. 2005. Glutamate transporter: An unexpected target for some antibiotics. Molecular Pain 1: 5. |
| Full Text & Related Files: |
1074355.pdf (196.5Kb; PDF) 
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| Abstract: | Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, Rothstein et al (2005) reports that the most commonly used class of antibiotics (β-lactam antibiotics) such as ceftriaxone promoted the expression of GLT1 and demonstrated a functional role in both in vitro and in vivo models of glutamate neurotocixity. These findings indicate that positive promoters of GT expression may have a unique role in neuroprotection through regulating GT expression. This is also encouraging in search for new pharmacological tools for pain management. |
| Published Version: | doi:10.1186/1744-8069-1-5 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074355/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8191179 |
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