Parasite-Mediated Evolution of the Functional Part of the MHC in Primates

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Parasite-Mediated Evolution of the Functional Part of the MHC in Primates

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dc.contributor.author Garamszegi, Laszlo Z.
dc.contributor.author Nunn, Charles Lindsay
dc.date.accessioned 2012-02-21T18:50:55Z
dc.date.issued 2011
dc.identifier.citation Garamszegi, Laszlo Z. and Charles L. Nunn. 2011. Parasite-mediated evolution of the functional part of the MHC in primates. Journal of Evolutionary Biology 24(1): 184–195. en_US
dc.identifier.issn 1010-061X en_US
dc.identifier.issn 1420-9101 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8191224
dc.description.abstract The major histocompatibility complex (MHC) is a key model of genetic polymorphism, but the mechanisms underlying its extreme variability are debated. Most hypotheses for MHC diversity focus on pathogen-driven selection and predict that MHC polymorphism evolves under the pressure of a diverse parasite fauna. Several studies reported that certain alleles offer protection against certain parasites, yet it remains unclear whether variation in parasite pressure more generally covaries with allelic diversity and rates of molecular evolution of MHC across species. We tested this prediction in a comparative study of 41 primate species. We characterized polymorphism of the exon 2 of DRB region of the MHC class II. Our phylogenetic analyses controlled for the potential effects of neutral mutation rate, population size, geographic origin and body mass and revealed that nematode species richness associates positively with nonsynonymous nucleotide substitution rate at the functional part of the molecule. We failed to find evidence for allelic diversity being strongly related to parasite species richness. Continental distribution was a strong predictor of both allelic diversity and substitution rate, with higher values in Malagasy and Neotropical primates. These results indicate that parasite pressure can influence the different estimates of MHC polymorphism, whereas geography plays an independent role in the natural history of MHC. en_US
dc.description.sponsorship Human Evolutionary Biology en_US
dc.language.iso en_US en_US
dc.publisher Wiley-Blackwell en_US
dc.relation.isversionof doi:10.1111/j.1420-9101.2010.02156.x en_US
dash.license OAP
dc.subject balancing selection en_US
dc.subject helminths en_US
dc.subject host–parasite coevolution en_US
dc.subject immune defence en_US
dc.subject immunogenetics en_US
dc.subject parasitism en_US
dc.subject phylogenetic comparative methods en_US
dc.title Parasite-Mediated Evolution of the Functional Part of the MHC in Primates en_US
dc.type Journal Article en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Journal of Evolutionary Biology en_US
dash.depositing.author Nunn, Charles Lindsay
dc.date.available 2012-02-21T18:50:55Z

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  • FAS Scholarly Articles [6868]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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