The RAS/Mitogen Activated Protein (MAP) Kinase Pathway in Melanoma Biology and Therapeutics
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The RAS/Mitogen Activated Protein (MAP) Kinase Pathway in Melanoma Biology and Therapeutics
| Title: | The RAS/Mitogen Activated Protein (MAP) Kinase Pathway in Melanoma Biology and Therapeutics |
| Author: |
Jarell, Abel D; Lawrence, Donald; Tsao, Hensin
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Jarell, Abel D, Donald Lawrence, and Hensin Tsao. 2007. The RAS/mitogen activated protein (MAP) kinase pathway in melanoma biology and therapeutics. Biologics : Targets & Therapy 1(4): 407-414. |
| Full Text & Related Files: |
2721285.pdf (322.9Kb; PDF) 
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| Abstract: | An effective treatment for metastatic melanoma remains one of the most elusive goals in all of oncology. Several generations of therapeutic trials have yet to yield any agents that can significantly prolong survival for widespread disease. Despite this disheartening history, our understanding of the biology and molecular genetics of melanoma hold the promise of a new era of molecular targets. One pathway that appears to be universally activated in and critically needed for melanoma growth is the Ras/mitogen activated protein (MAP) kinase signaling cascade. Since the enzymatic functions of the signaling partners are well characterized, this pathway offers many potential “druggable” candidates including Braf, Mek and Ras itself. In this review, we describe this pathway in the context of melanoma tumorigenesis and discuss some of the current relevant pharmacologic treatments and clinical trials. |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721285/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8268110 |
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