The RAS/Mitogen Activated Protein (MAP) Kinase Pathway in Melanoma Biology and Therapeutics

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The RAS/Mitogen Activated Protein (MAP) Kinase Pathway in Melanoma Biology and Therapeutics

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dc.contributor.author Jarell, Abel D
dc.contributor.author Lawrence, Donald
dc.contributor.author Tsao, Hensin
dc.date.accessioned 2012-02-28T16:25:39Z
dc.date.issued 2007
dc.identifier.citation Jarell, Abel D, Donald Lawrence, and Hensin Tsao. 2007. The RAS/mitogen activated protein (MAP) kinase pathway in melanoma biology and therapeutics. Biologics : Targets & Therapy 1(4): 407-414. en_US
dc.identifier.issn 1177-5475 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8268110
dc.description.abstract An effective treatment for metastatic melanoma remains one of the most elusive goals in all of oncology. Several generations of therapeutic trials have yet to yield any agents that can significantly prolong survival for widespread disease. Despite this disheartening history, our understanding of the biology and molecular genetics of melanoma hold the promise of a new era of molecular targets. One pathway that appears to be universally activated in and critically needed for melanoma growth is the Ras/mitogen activated protein (MAP) kinase signaling cascade. Since the enzymatic functions of the signaling partners are well characterized, this pathway offers many potential “druggable” candidates including Braf, Mek and Ras itself. In this review, we describe this pathway in the context of melanoma tumorigenesis and discuss some of the current relevant pharmacologic treatments and clinical trials. en_US
dc.language.iso en_US en_US
dc.publisher Dove Medical Press en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721285/pdf/ en_US
dash.license LAA
dc.subject malignant melanoma en_US
dc.subject therapeutics en_US
dc.subject chemotherapy en_US
dc.subject RAS en_US
dc.subject MAP kinase en_US
dc.title The RAS/Mitogen Activated Protein (MAP) Kinase Pathway in Melanoma Biology and Therapeutics en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Biologics: Targets & Therapy en_US
dash.depositing.author Tsao, Hensin
dc.date.available 2012-02-28T16:25:39Z
dash.affiliation.other HMS^Health Sciences and Technology en_US
dash.affiliation.other HMS^Dermatology-Massachusetts General Hospital en_US

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