Factors Determining the Persistence or Recurrence of Well-Differentiated Thyroid Cancer Treated by Thyroidectomy and/or Radioiodine in the Boston, Massachusetts Area: A Retrospective Chart Review

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Factors Determining the Persistence or Recurrence of Well-Differentiated Thyroid Cancer Treated by Thyroidectomy and/or Radioiodine in the Boston, Massachusetts Area: A Retrospective Chart Review

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dc.contributor.author Leung, Angela M.
dc.contributor.author Dave, Shalini
dc.contributor.author Lee, Stephanie L.
dc.contributor.author Campion, Francis X.
dc.contributor.author Garber, Jeffrey Richard
dc.contributor.author Pearce, Elizabeth N.
dc.date.accessioned 2012-03-12T03:59:25Z
dc.date.issued 2011
dc.identifier.citation Leung, Angela M., Shalini Dave, Stephanie L. Lee, Francis X. Campion, Jeffrey R. Garber, and Elizabeth N. Pearce. 2011. Factors determining the persistence or recurrence of well-differentiated thyroid cancer treated by thyroidectomy and/or radioiodine in the Boston, Massachusetts area: A retrospective chart review. Thyroid Research 4: 9. en_US
dc.identifier.issn 1756-6614 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8347352
dc.description.abstract Objective: To assess predictors of well-differentiated thyroid cancer (WDTC) persistence/recurrence. Design: This was a retrospective chart review of thyroid carcinoma patients seen 1979-2007 in a Boston, Massachusetts-area multispecialty group. Of 1,025 patients, 431 met eligibility criteria. Cox proportional hazards models were used to assess predictors (gender, age, ethnicity, tumor size, surgical histology) of WDTC persistence/recurrence (elevated thyroglobulin levels with negative thyroglobulin-antibodies; or positive imaging). Local extension of disease and lymph node involvement could not be assessed. Results: Mean age at initial surgery (n = 431, 74% women, 79% Caucasian) was 45.8 \(\pm\) 13.5(SD) years. Mean tumor (papillary, 91%; follicular, 5%; Hurthle cell, 2%; \(\ge\)1 type, 2%) size was 2.5 \(\pm\) 1.6(SD) cm. Most tumors were unifocal (57%) and \(\ge\)1 cm (89%). Over 2,600 person-years of follow-up, persistence/recurrence occurred in 52 patients (12%) 4.3 years (median; range 0.2-23.2 years) after surgery. Gender, ethnicity, tumor size, multifocality, and histology were not predictive of persistence/recurrence, while older age was predictive in some models. Conclusions: In WDTC patients treated by total and near total thyroidectomy and radioiodine and analyzed without consideration of local, locoregional, and distant extent of disease, neither size of tumor nor male gender contribute to disease persistence/recurrence. Age at diagnosis seems to have some positive prognostic value even if only patients older than 21 years at diagnosis are considered. Due to the rare occurrence of follicular (also oxyphilic) histotype, this conclusion refers mainly to patients with papillary thyroid cancer. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof 10.1186/1756-6614-4-7 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090368/pdf/ en_US
dash.license LAA
dc.title Factors Determining the Persistence or Recurrence of Well-Differentiated Thyroid Cancer Treated by Thyroidectomy and/or Radioiodine in the Boston, Massachusetts Area: A Retrospective Chart Review en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Thyroid Research en_US
dash.depositing.author Campion, Francis X.
dc.date.available 2012-03-12T03:59:25Z
dash.affiliation.other 100125 en_US
dash.affiliation.other 100176 en_US

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