Pathogenic Infection of Macaca Nemestrina with a CCR5-tropic Subtype-C Simian-human Immunodeficiency Virus

DSpace/Manakin Repository

Pathogenic Infection of Macaca Nemestrina with a CCR5-tropic Subtype-C Simian-human Immunodeficiency Virus

Citable link to this page

. . . . . .

Title: Pathogenic Infection of Macaca Nemestrina with a CCR5-tropic Subtype-C Simian-human Immunodeficiency Virus
Author: Ho, On; Larsen, Kay; Polacino, Patricia; Song, Ruijiang; Hu, Shiu-Lok; Li, Yun; Anderson, David; Ruprecht, Ruth Margrit

Note: Order does not necessarily reflect citation order of authors.

Citation: Ho, On, Kay Larsen, Patricia Polacino, Yun Li, David Anderson, Ruijiang Song, Ruth M. Ruprecht, and Shiu-Lok Hu. 2009. Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virus. Retrovirology 6: 65.
Full Text & Related Files:
Abstract: Background: Although pig-tailed macaques (Macaca nemestrina) have been used in AIDS research for years, less is known about the early immunopathogenic events in this species, as compared to rhesus macaques (Macaca mulatta). Similarly, the events in early infection are well-characterized for simian immunodeficiency viruses (SIV), but less so for chimeric simian-human immunodeficiency viruses (SHIV), although the latter have been widely used in HIV vaccine studies. Here, we report the consequences of intrarectal infection with a CCR5-tropic clade C SHIV-1157ipd3N4 in pig-tailed macaques. Results: Plasma and cell-associated virus was detectable in peripheral blood and intestinal tissues of all four pig-tailed macaques following intrarectal inoculation with SHIV-1157ipd3N4. We also observed a rapid and irreversible loss of CD4+ T cells at multiple mucosal sites, resulting in a marked decrease of CD4:CD8 T cell ratios 0.5–4 weeks after inoculation. This depletion targeted subsets of CD4+ T cells expressing the CCR5 coreceptor and having a CD28-CD95+ effector memory phenotype, consistent with the R5-tropism of SHIV-1157ipd3N4. All three animals that were studied beyond the acute phase seroconverted as early as week 4, with two developing cross-clade neutralizing antibody responses by week 24. These two animals also demonstrated persistent plasma viremia for >48 weeks. One of these animals developed AIDS, as shown by peripheral blood CD4+ T-cell depletion starting at 20 weeks post inoculation. Conclusion: These findings indicate that SHIV-1157ipd3N4-induced pathogenesis in pig-tailed macaques followed a similar course as SIV-infected rhesus macaques. Thus, R5 SHIV-C-infection of pig-tailed macaques could provide a useful and relevant model for AIDS vaccine and pathogenesis research.
Published Version: doi:10.1186/1742-4690-6-65
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720380/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8438165

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters