Quantitative Investigation of the Effect of the Extra-Cerebral Vasculature in Diffuse Optical Imaging: A Simulation Study

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Quantitative Investigation of the Effect of the Extra-Cerebral Vasculature in Diffuse Optical Imaging: A Simulation Study

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dc.contributor.author Dehaes, Mathieu
dc.contributor.author Gagnon, Louis
dc.contributor.author Lesage, Frederic
dc.contributor.author Pelegrini-Issac, Melanie
dc.contributor.author Vignaud, Alexandre
dc.contributor.author Valabregue, Romain
dc.contributor.author Grebe, Reinhard
dc.contributor.author Wallois, Fabrice
dc.contributor.author Benali, Habib
dc.date.accessioned 2012-03-29T03:21:31Z
dc.date.issued 2011
dc.identifier.citation Dehaes, Mathieu, Louis Gagnon, Frederic Lesage, Melanie Pelegrini-Issac, Alexandre Vignaud, Romain Valabregue, Reinhard Grebe, Fabrice Wallois, and Habib Benali. 2011. Quantitative investigation of the effect of the extra-cerebral vasculature in diffuse optical imaging: A simulation study. Biomedical Optics Express 2(3): 680-695. en_US
dc.identifier.issn 2156-7085 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8461941
dc.description.abstract Diffuse optical imaging (DOI) is a non invasive technique allowing the recovery of hemodynamic changes in the brain. Due to the diffusive nature of photon propagation in turbid media and the fact that cerebral tissues are located around 1.5 cm under the adult human scalp, DOI measurements are subject to partial volume errors. DOI measurements are also sensitive to large pial vessels because oxygenated and deoxygenated hemoglobin are the dominant chromophores in the near infrared window. In this study, the effect of the extra-cerebral vasculature in proximity of the sagittal sinus was investigated for its impact on DOI measurements simulated over the human adult visual cortex. Numerical Monte Carlo simulations were performed on two specific models of the human head derived from magnetic resonance imaging (MRI) scans. The first model included the extra-cerebral vasculature in which constant hemoglobin concentrations were assumed while the second did not. The screening effect of the vasculature was quantified by comparing recovered hemoglobin changes from each model for different optical arrays and regions of activation. A correction factor accounting for the difference between the recovered and the simulated hemoglobin changes was computed in each case. The results show that changes in hemoglobin concentration are better estimated when the extra-cerebral vasculature is modeled and the correction factors obtained in this case were at least 1.4-fold lower. The effect of the vasculature was also examined in a high-density diffuse optical tomography configuration. In this case, the difference between changes in hemoglobin concentration recovered with each model was reduced down to 10%. en_US
dc.language.iso en_US en_US
dc.publisher Optical Society of America en_US
dc.relation.isversionof doi:10.1364/BOE.2.000680 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047372/pdf/ en_US
dash.license LAA
dc.title Quantitative Investigation of the Effect of the Extra-Cerebral Vasculature in Diffuse Optical Imaging: A Simulation Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Biomedical Optics Express en_US
dash.depositing.author Dehaes, Mathieu
dc.date.available 2012-03-29T03:21:31Z
dash.affiliation.other 100174 en_US

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