Yohimbine-Induced Amygdala Activation in Pathological Gamblers: A Pilot Study

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Yohimbine-Induced Amygdala Activation in Pathological Gamblers: A Pilot Study

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dc.contributor.author Tschibelu, Evelyne
dc.contributor.author Elman, Igor
dc.contributor.author Becerra, Lino Renan
dc.contributor.author Yamamoto, Rinah Tikvah
dc.contributor.author George, Edward E.
dc.contributor.author Borsook, David
dc.date.accessioned 2012-03-29T17:43:55Z
dc.date.issued 2012
dc.identifier.citation Elman, Igor, Lino Becerra, Evelyne Tschibelu, Rinah Yamamoto, Edward George, and David Borsook. 2012. Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. PLoS ONE 7(2): e31118. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8462347
dc.description.abstract Rationale and Objectives: There is evidence that drug addiction is associated with increased physiological and psychological responses to stress. In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological gambling (PG), is likewise associated with an enhanced response to stress. Methods We induced stress by injecting yohimbine (0.2–0.3 mg/kg, IV), an alpha-2 adrenoceptor antagonist that elicits stress-like physiological and psychological effects in humans and in laboratory animals, to four subjects with PG and to five non-gamblers mentally healthy control subjects. Their fMRI brain responses were assessed along with subjective stress and gambling urges ratings. Results: Voxelwise analyses of data sets from individual subjects, utilizing generalized linear model approach, revealed significant left amygdala activation in response to yohimbine across all PG subjects. This amygdala effect was not observed in the five control individuals. Yohimbine elicited subjective stress ratings in both groups with greater (albeit not statically significantly) average response in the PG subjects. On the other hand, yohimbine did not induce urges to gamble. Conclusions: The present data support the hypothesis of brain sensitization to pharmacologically-induced stress in PG. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0031118 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271103/pdf/ en_US
dash.license LAA
dc.subject biology en_US
dc.subject neuroscience en_US
dc.subject neuroimaging en_US
dc.subject medicine en_US
dc.subject mental health en_US
dc.subject psychiatry en_US
dc.subject psychology en_US
dc.subject behavior en_US
dc.title Yohimbine-Induced Amygdala Activation in Pathological Gamblers: A Pilot Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Borsook, David
dc.date.available 2012-03-29T17:43:55Z

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