A New Concept for Cancer Therapy: Out-Competing the Aggressor

DSpace/Manakin Repository

A New Concept for Cancer Therapy: Out-Competing the Aggressor

Citable link to this page

. . . . . .

Title: A New Concept for Cancer Therapy: Out-Competing the Aggressor
Author: Deisboeck, Thomas Steve; Wang, Zhihui

Note: Order does not necessarily reflect citation order of authors.

Citation: Deisboeck, Thomas S. and Zhihui Wang. 2008. A new concept for cancer therapy: out-competing the aggressor. Cancer Cell International 8(1): 19.
Full Text & Related Files:
Abstract: Cancer expansion depends on host organ conditions that permit growth. Since such microenvironmental nourishment is limited we argue here that an autologous, therapeutically engineered and faster metabolizing cell strain could potentially out-compete native cancer cell populations for available resources which in turn should contain further cancer growth. This hypothesis aims on turning cancer progression, and its microenvironmental dependency, into a therapeutic opportunity. To illustrate our concept, we developed a three-dimensional computational model that allowed us to investigate the growth dynamics of native tumor cells mixed with genetically engineered cells that exhibit a higher proliferation rate. The simulation results confirm in silico efficacy of such therapeutic cells to combating cancer cells on site in that they can indeed control tumor growth once their proliferation rate exceeds a certain level. While intriguing from a theoretical perspective, this bold, innovative ecology-driven concept bears some significant challenges that warrant critical discussion in the community for further refinement.
Published Version: doi:10.1186/1475-2867-8-19
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628876/pdf/
http://www.cancerci.com/content/8/1/19
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8480659

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters