Rapid and Adaptive Evolution of MHC Genes Under Parasite Selection in Experimental Vertebrate Populations

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Rapid and Adaptive Evolution of MHC Genes Under Parasite Selection in Experimental Vertebrate Populations

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dc.contributor.author Eizaguirre, Christophe
dc.contributor.author Kalbe, Martin
dc.contributor.author Milinski, Manfred
dc.contributor.author Lenz, Tobias Leander
dc.date.accessioned 2012-04-08T19:00:19Z
dc.date.issued 2012
dc.identifier.citation Eizaguirre, Christophe, Tobias L. Lenz, Martin Kalbe, and Manfred Milinski. 2012. Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations. Nature Communications 3:621. en_US
dc.identifier.issn 2041-1723 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8519637
dc.description.abstract The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocompatibility complex genes have a crucial function in the adaptive immune system by presenting parasite-derived antigens to T lymphocytes. Because of this function, varying parasite-mediated selection has been proposed as a major evolutionary force for maintaining major histocompatibility complex polymorphism. A necessary prerequisite of such a balancing selection process is rapid major histocompatibility complex allele frequency shifts resulting from emerging selection by a specific parasite. Here we show in six experimental populations of sticklebacks, each exposed to one of two different parasites, that only those major histocompatibility complex alleles providing resistance to the respective specific parasite increased in frequency in the next host generation. This result demonstrates experimentally that varying parasite selection causes rapid adaptive evolutionary changes, thus facilitating the maintenance of major histocompatibility complex polymorphism. en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof doi://10.1038/ncomms1632 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272583/pdf/ en_US
dash.license LAA
dc.title Rapid and Adaptive Evolution of MHC Genes Under Parasite Selection in Experimental Vertebrate Populations en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Nature Communications en_US
dash.depositing.author Lenz, Tobias Leander
dc.date.available 2012-04-08T19:00:19Z

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