Targeting Autophagy Addiction in Cancer

Targeting Autophagy Addiction in Cancer

DSpace/Manakin Repository

Targeting Autophagy Addiction in Cancer

dc.contributor.author	Mancias, Joseph Douglas
dc.contributor.author	Kimmelman, Alec C.
dc.date.accessioned	2012-04-08T19:01:01Z
dc.date.issued	2011
dc.identifier.citation	Mancias, Joseph D., and Alec C. Kimmelman. 2011. Targeting Autophagy Addiction in Cancer. Oncotarget 12(2): 1302-1306.	en_US
dc.identifier.issn	1949-2553	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:8519638
dc.description.abstract	Autophagy inhibition is a novel cancer therapeutic strategy in the early stages of clinical trial testing. The initial rationale for using autophagy inhibition was generated by research revealing that autophagy is upregulated in response to external stresses, including chemotherapy and radiotherapy. Combining autophagy inhibition with agents that induce autophagy as a pro-survival response may therefore increase their therapeutic efficacy. Recent research has shown that some cancer cells, particularly those driven by the K-Ras oncogene, also depend on elevated levels of autophagy for survival even in the absence of external stressors. In multiple in vitro as well as in vivo systems, oncogenic Ras-mediated transformation and tumor growth are dependent on autophagy to evade metabolic stress and cell death. These studies have subsequently led to further early phase clinical testing whether autophagy inhibition is a viable and effective strategy for targeting Ras-driven tumors. Even before the clinical results are available from these ongoing clinical trials, much work remains to optimally develop the approach of autophagy inhibition clinically; most notably reliably detecting levels of autophagy in human tumor samples, pharmacodynamics of currently available autophagy inhibitors (chloroquine and the derivative hydroxychloroquine), and new target identification and drug development.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Impact Journals LLC	en_US
dc.relation.isversionof	http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=384	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282086/pdf/	en_US
dash.license	LAA
dc.subject	autophagy	en_US
dc.subject	Ras	en_US
dc.subject	metabolism	en_US
dc.subject	cancer	en_US
dc.subject	tumor	en_US
dc.subject	therapy	en_US
dc.title	Targeting Autophagy Addiction in Cancer	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Oncotarget	en_US
dash.depositing.author	Kimmelman, Alec C.
dc.date.available	2012-04-08T19:01:01Z