Magnetic Resonance Characterization of Ischemic Tissue Metabolism

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Magnetic Resonance Characterization of Ischemic Tissue Metabolism

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Title: Magnetic Resonance Characterization of Ischemic Tissue Metabolism
Author: Cheung, Jerry S; Wang, Xiaoying; Sun, Phillip Zhe

Note: Order does not necessarily reflect citation order of authors.

Citation: Cheung, Jerry S, Xiaoying Wang, and Phillip Zhe Sun. 2011. Magnetic resonance characterization of ischemic tissue metabolism. The Open Neuroimaging Journal 5(Suppl. 1-M2):66-73.
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Abstract: Magnetic resonance imaging (MRI) and spectroscopy (MRS) are versatile diagnostic techniques capable of characterizing the complex stroke pathophysiology, and hold great promise for guiding stroke treatment. Particularly, tissue viability and salvageability are closely associated with its metabolic status. Upon ischemia, ischemic tissue metabolism is disrupted including altered metabolism of glucose and oxygen, elevated lactate production/accumulation, tissue acidification and eventually, adenosine triphosphate (ATP) depletion and energy failure. Whereas metabolism impairment during ischemic stroke is complex, it may be monitored non-invasively with magnetic resonance (MR)-based techniques. Our current article provides a concise overview of stroke pathology, conventional and emerging imaging and spectroscopy techniques, and data analysis tools for characterizing ischemic tissue damage.
Published Version: doi:10.2174/1874440001105010066
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245409/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8519640

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