Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study

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Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study

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dc.contributor.author Mordukhovich, Irina
dc.contributor.author Hu, Howard
dc.contributor.author Wright, Robert O.
dc.contributor.author Amarasiriwardena, Chitra J.
dc.contributor.author Baccarelli, Andrea
dc.contributor.author Litonjua, Augusto Ampil
dc.contributor.author Sparrow, David
dc.contributor.author Vokonas, Pantel S
dc.contributor.author Schwartz, Joel David
dc.date.accessioned 2012-04-17T19:23:46Z
dc.date.issued 2012
dc.identifier.citation Mordukhovich, Irina, Robert O. Wright, Howard Hu, Chitra Amarasiriwardena, Andrea Baccarelli, Augusto Litonjua, David Sparrow, Pantel Vokonas, and Joel Schwartz. 2012. Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the normative aging study. Environmental Health Perspectives 120(1): 98-104. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8589347
dc.description.abstract Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts.: Objectives: We hypothesized that chronic arsenic, cadmium, mercury, and lead exposures elevate BP and that manganese lowers BP.: Methods: We conducted a cross-sectional analysis of associations between toenail metals and BP among older men from the Normative Aging Study (n = 639), using linear regression and adjusting for potential confounders. Results: An interquartile range increase in toenail arsenic was associated with higher systolic BP [0.93 mmHg; 95% confidence interval (CI): 0.25, 1.62] and pulse pressure (0.76 mmHg; 95% CI: 0.22, 1.30). Positive associations between arsenic and BP and negative associations between manganese and BP were strengthened in models adjusted for other toenail metals.: Conclusions: Our findings suggest associations between BP and arsenic and manganese. This may be of public health importance because of prevalence of both metal exposure and cardiovascular disease. Results should be interpreted cautiously given potential limitations of toenails as biomarkers of metal exposure.: en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi:10.1289/ehp.1002805 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261928/pdf/ en_US
dash.license LAA
dc.title Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Wright, Robert O.
dc.date.available 2012-04-17T19:23:46Z

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