Multidrug-Resistant Tuberculosis Management in Resource-Limited Settings
| Title: | Multidrug-Resistant Tuberculosis Management in Resource-Limited Settings |
| Author: |
Nathanson, Eva; Lambregts-van Weezenbeek, Catharina; Gupta, Rajesh; Blöndal, Kai; Caminero, José A.; Cegielski, J. Peter; Danilovits, Manfred; Espinal, Marcos A.; Hollo, Vahur; Jaramillo, Ernesto; Leimane, Vaira; Nunn, Paul; Pasechnikov, Alexander; Tupasi, Thelma; Wells, Charles; Raviglione, Mario C.; Rich, Michael Leonard; Bayona, Jaime; Mitnick, Carole Diane; Mukherjee, Joia Stapleton
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Nathanson, Eva, Catharina Lambregts-van Weezenbeek, Michael L. Rich, Rajesh Gupta, Jaime Bayona, Kai Blöndal, José A. Caminero, et al. 2006. Multidrug-resistant tuberculosis management in resource-limited settings. Emerging Infectious Diseases 12(9): 1389-1397. |
| Full Text & Related Files: |
3294733.pdf (334.8Kb; PDF) 
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| Abstract: | Evidence of successful management of multidrug-resistant tuberculosis (MDRTB) is mainly generated from referral hospitals in high-income countries. We evaluate the management of MDRTB in 5 resource-limited countries: Estonia, Latvia, Peru, the Philippines, and the Russian Federation. All projects were approved by the Green Light Committee for access to quality-assured second-line drugs provided at reduced price for MDRTB management. Of 1,047 MDRTB patients evaluated, 119 (11%) were new, and 928 (89%) had received treatment previously. More than 50% of previously treated patients had received both first- and second-line drugs, and 65% of all patients had infections that were resistant to both first- and second-line drugs. Treatment was successful in 70% of all patients, but success rate was higher among new (77%) than among previously treated patients (69%). In resource-limited settings, treatment of MDRTB provided through, or in collaboration with, national TB programs can yield results similar to those from wealthier settings. |
| Published Version: | doi:10.3201/eid1209.051618 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294733/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8609125 |
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