Efficacy of Infection Control Interventions in Reducing the Spread of Multidrug-Resistant Organisms in the Hospital Setting

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Efficacy of Infection Control Interventions in Reducing the Spread of Multidrug-Resistant Organisms in the Hospital Setting

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Title: Efficacy of Infection Control Interventions in Reducing the Spread of Multidrug-Resistant Organisms in the Hospital Setting
Author: Horn, Mary Ann; Ruan, Shigui; Webb, Glenn F.; Wares, Joanna R.; D'Agata, Erika Maria Concetta

Note: Order does not necessarily reflect citation order of authors.

Citation: D'Agata, Erika M. C., Mary Ann Horn, Shigui Ruan, Glenn F. Webb, and Joanna R. Wares. 2012. Efficacy of infection control interventions in reducing the spread of multidrug-resistant organisms in the hospital setting. PLoS ONE 7(2): e30170.
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Abstract: Multidrug-resistant organisms (MDRO) continue to spread in hospitals globally, but the population-level impact of recommended preventive strategies and the relative benefit of individual strategies targeting all MDRO in the hospital setting are unclear. To explore the dynamics of MDRO transmission in the hospital, we develop a model extending data from clinical individual-level studies to quantify the impact of hand hygiene, contact precautions, reducing antimicrobial exposure and screening surveillance cultures in decreasing the prevalence of MDRO colonization and infection. The effect of an ongoing increase in the influx of patients colonized with MDRO into the hospital setting is also quantified. We find that most recommended strategies have substantial effect in decreasing the prevalence of MDRO over time. However, screening for asymptomatic MDRO colonization among patients who are not receiving antimicrobials is of minimal value in reducing the spread of MDRO.
Published Version: doi:10.1371/journal.pone.0030170
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282714/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8645497

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