Prevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetope

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Prevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetope

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Title: Prevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetope
Author: Weigmann, Benno; Daniel, Carolin; Bronson, Roderick Terry; von Boehmer, Harald

Note: Order does not necessarily reflect citation order of authors.

Citation: Daniel, Carolin, Benno Weigmann, Roderick Bronson, and Harald von Boehmer. 2011. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. Journal of Experimental Medicine 208(7): 1501-1510.
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Abstract: Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A\(^{g7}\) molecules of nonobese diabetic (NOD) mice, which results in weak agonistic activity of the peptide MHC complex. Here, we describe a strongly agonistic insulin mimetope that effectively converts naive T cells into Foxp3\(^+\) regulatory T cells in vivo, thereby completely preventing T1D in NOD mice. In contrast, natural insulin epitopes are ineffective. Subimmunogenic vaccination with strongly agonistic insulin mimetopes might represent a novel strategy to prevent T1D in humans at risk for the disease.
Published Version: doi:10.1084/jem.20110574
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135372/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8646759

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