Prevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetope
DSpace/Manakin Repository
Prevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetope
| Title: | Prevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetope |
| Author: |
Weigmann, Benno; Daniel, Carolin; Bronson, Roderick Terry; von Boehmer, Harald
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Daniel, Carolin, Benno Weigmann, Roderick Bronson, and Harald von Boehmer. 2011. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. Journal of Experimental Medicine 208(7): 1501-1510. |
| Full Text & Related Files: |
3135372.pdf (2.823Mb; PDF) 
|
| Abstract: | Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A\(^{g7}\) molecules of nonobese diabetic (NOD) mice, which results in weak agonistic activity of the peptide MHC complex. Here, we describe a strongly agonistic insulin mimetope that effectively converts naive T cells into Foxp3\(^+\) regulatory T cells in vivo, thereby completely preventing T1D in NOD mice. In contrast, natural insulin epitopes are ineffective. Subimmunogenic vaccination with strongly agonistic insulin mimetopes might represent a novel strategy to prevent T1D in humans at risk for the disease. |
| Published Version: | doi:10.1084/jem.20110574 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135372/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8646759 |
This item appears in the following Collection(s)
-
HMS Scholarly Articles [4046]
Contact administrator regarding this item (to report mistakes or request changes)
