Evidence for Transcript Networks Composed of Chimeric RNAs in Human Cells

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Evidence for Transcript Networks Composed of Chimeric RNAs in Human Cells

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dc.contributor.author Djebali, Sarah
dc.contributor.author Lagarde, Julien
dc.contributor.author Kapranov, Philipp
dc.contributor.author Lacroix, Vincent
dc.contributor.author Borel, Christelle
dc.contributor.author Mudge, Jonathan M.
dc.contributor.author Howald, Cédric
dc.contributor.author Foissac, Sylvain
dc.contributor.author Ucla, Catherine
dc.contributor.author Chrast, Jacqueline
dc.contributor.author Ribeca, Paolo
dc.contributor.author Murray, Ryan R.
dc.contributor.author Lin, Chenwei
dc.contributor.author Bell, Ian
dc.contributor.author Dumais, Erica
dc.contributor.author Drenkow, Jorg
dc.contributor.author Tress, Michael L.
dc.contributor.author Gelpí, Josep Lluís
dc.contributor.author Orozco, Modesto
dc.contributor.author Valencia, Alfonso
dc.contributor.author van Berkum, Nynke L.
dc.contributor.author Lajoie, Bryan R.
dc.contributor.author Stamatoyannopoulos, John
dc.contributor.author Batut, Philippe
dc.contributor.author Dobin, Alex
dc.contributor.author Harrow, Jennifer
dc.contributor.author Hubbard, Tim
dc.contributor.author Dekker, Job
dc.contributor.author Frankish, Adam
dc.contributor.author Salehi-Ashtiani, Kourosh
dc.contributor.author Reymond, Alexandre
dc.contributor.author Antonarakis, Stylianos E.
dc.contributor.author Guigó, Roderic
dc.contributor.author Gingeras, Thomas R.
dc.contributor.author Martin, David
dc.contributor.author Yang, Xinping
dc.contributor.author Ghamsari, Lila
dc.contributor.author Vidal, Marc
dc.date.accessioned 2012-05-01T20:00:05Z
dc.date.issued 2012
dc.identifier.citation Djebali, Sarah, Julien Lagarde, Philipp Kapranov, Vincent Lacroix, Christelle Borel, Jonathan M. Mudge, Cédric Howald, et al. 2012. Evidence for transcript networks composed of chimeric rnas in human cells. PLoS ONE 7(1): e28213. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8646773
dc.description.abstract The classic organization of a gene structure has followed the Jacob and Monod bacterial gene model proposed more than 50 years ago. Since then, empirical determinations of the complexity of the transcriptomes found in yeast to human has blurred the definition and physical boundaries of genes. Using multiple analysis approaches we have characterized individual gene boundaries mapping on human chromosomes 21 and 22. Analyses of the locations of the 5′ and 3′ transcriptional termini of 492 protein coding genes revealed that for 85% of these genes the boundaries extend beyond the current annotated termini, most often connecting with exons of transcripts from other well annotated genes. The biological and evolutionary importance of these chimeric transcripts is underscored by (1) the non-random interconnections of genes involved, (2) the greater phylogenetic depth of the genes involved in many chimeric interactions, (3) the coordination of the expression of connected genes and (4) the close in vivo and three dimensional proximity of the genomic regions being transcribed and contributing to parts of the chimeric RNAs. The non-random nature of the connection of the genes involved suggest that chimeric transcripts should not be studied in isolation, but together, as an RNA network. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0028213 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251577/pdf/ en_US
dash.license LAA
dc.title Evidence for Transcript Networks Composed of Chimeric RNAs in Human Cells en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Yang, Xinping
dc.date.available 2012-05-01T20:00:05Z

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