RIC-7 Promotes Neuropeptide Secretion

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RIC-7 Promotes Neuropeptide Secretion

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dc.contributor.author Sieburth, Derek
dc.contributor.author Hao, Yingsong
dc.contributor.author Hu, Zhitao
dc.contributor.author Kaplan, Joshua M.
dc.date.accessioned 2012-05-09T01:02:38Z
dc.date.issued 2012
dc.identifier.citation Hao, Yingsong, Zhitao Hu, Derek Sieburth, and Joshua M. Kaplan. 2012. Ric-7 promotes neuropeptide secretion. PLoS Genetics 8(1): e1002464. en_US
dc.identifier.issn 1553-7390 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8704122
dc.description.abstract Secretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles, synaptic vesicles (SVs) and dense core vesicles (DCVs) respectively. Relatively little is known about factors that differentially regulate SV and DCV secretion. Here we identify a novel protein RIC-7 that is required for neuropeptide secretion in Caenorhabditis elegans. The RIC-7 protein is expressed in all neurons and is localized to presynaptic terminals. Imaging, electrophysiology, and behavioral analysis of ric-7 mutants indicates that acetylcholine release occurs normally, while neuropeptide release is significantly decreased. These results suggest that RIC-7 promotes DCV–mediated secretion. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1002464 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261915/pdf/ en_US
dash.license LAA
dc.title RIC-7 Promotes Neuropeptide Secretion en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Genetics en_US
dash.depositing.author Hao, Yingsong
dc.date.available 2012-05-09T01:02:38Z

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