A Web-Based Normative Calculator for the Uniform Data Set (UDS) Neuropsychological Test Battery

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A Web-Based Normative Calculator for the Uniform Data Set (UDS) Neuropsychological Test Battery

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dc.contributor.author Shirk, Steven D
dc.contributor.author Weintraub, Sandra
dc.contributor.author Mitchell, Meghan B
dc.contributor.author Shaughnhessy, Lynn W
dc.contributor.author Sherman, Janet Cohen
dc.contributor.author Locascio, Joseph J
dc.contributor.author Atri, Alireza
dc.date.accessioned 2012-05-10T18:07:28Z
dc.date.issued 2011
dc.identifier.citation Shirk, Steven D, Meghan B Mitchell, Lynn W Shaughnessy, Janet C Sherman, Joseph J Locascio, Sandra Weintraub, and Alireza Atri. 2011. A web-based normative calculator for the uniform data set (uds) neuropsychological test battery. Alzheimer's Research & Therapy 3(6): 32. en_US
dc.identifier.issn 1758-9193 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8715715
dc.description.abstract Introduction: With the recent publication of new criteria for the diagnosis of preclinical Alzheimer's disease (AD), there is a need for neuropsychological tools that take premorbid functioning into account in order to detect subtle cognitive decline. Using demographic adjustments is one method for increasing the sensitivity of commonly used measures. We sought to provide a useful online z-score calculator that yields estimates of percentile ranges and adjusts individual performance based on sex, age and/or education for each of the neuropsychological tests of the National Alzheimer's Coordinating Center Uniform Data Set (NACC, UDS). In addition, we aimed to provide an easily accessible method of creating norms for other clinical researchers for their own, unique data sets. Methods: Data from 3,268 clinically cognitively-normal older UDS subjects from a cohort reported by Weintraub and colleagues (2009) were included. For all neuropsychological tests, z-scores were estimated by subtracting the raw score from the predicted mean and then dividing this difference score by the root mean squared error term (RMSE) for a given linear regression model. Results: For each neuropsychological test, an estimated z-score was calculated for any raw score based on five different models that adjust for the demographic predictors of SEX, AGE and EDUCATION, either concurrently, individually or without covariates. The interactive online calculator allows the entry of a raw score and provides five corresponding estimated z-scores based on predictions from each corresponding linear regression model. The calculator produces percentile ranks and graphical output. Conclusions: An interactive, regression-based, normative score online calculator was created to serve as an additional resource for UDS clinical researchers, especially in guiding interpretation of individual performances that appear to fall in borderline realms and may be of particular utility for operationalizing subtle cognitive impairment present according to the newly proposed criteria for Stage 3 preclinical Alzheimer's disease. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/alzrt94 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308021/pdf/ en_US
dash.license LAA
dc.subject Alzheimer's disease en_US
dc.subject cognitive aging en_US
dc.subject mci en_US
dc.subject memory en_US
dc.subject norms en_US
dc.title A Web-Based Normative Calculator for the Uniform Data Set (UDS) Neuropsychological Test Battery en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Alzheimer's Research & Therapy en_US
dash.depositing.author Sherman, Janet Cohen
dc.date.available 2012-05-10T18:07:28Z

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