Show simple item record

dc.contributor.authorShirk, Steven D
dc.contributor.authorWeintraub, Sandra
dc.contributor.authorMitchell, Meghan B
dc.contributor.authorShaughnhessy, Lynn W
dc.contributor.authorSherman, Janet Cohen
dc.contributor.authorLocascio, Joseph J
dc.contributor.authorAtri, Alireza
dc.date.accessioned2012-05-10T18:07:28Z
dc.date.issued2011
dc.identifier.citationShirk, Steven D, Meghan B Mitchell, Lynn W Shaughnessy, Janet C Sherman, Joseph J Locascio, Sandra Weintraub, and Alireza Atri. 2011. A web-based normative calculator for the uniform data set (uds) neuropsychological test battery. Alzheimer's Research & Therapy 3(6): 32.en_US
dc.identifier.issn1758-9193en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8715715
dc.description.abstractIntroduction: With the recent publication of new criteria for the diagnosis of preclinical Alzheimer's disease (AD), there is a need for neuropsychological tools that take premorbid functioning into account in order to detect subtle cognitive decline. Using demographic adjustments is one method for increasing the sensitivity of commonly used measures. We sought to provide a useful online z-score calculator that yields estimates of percentile ranges and adjusts individual performance based on sex, age and/or education for each of the neuropsychological tests of the National Alzheimer's Coordinating Center Uniform Data Set (NACC, UDS). In addition, we aimed to provide an easily accessible method of creating norms for other clinical researchers for their own, unique data sets. Methods: Data from 3,268 clinically cognitively-normal older UDS subjects from a cohort reported by Weintraub and colleagues (2009) were included. For all neuropsychological tests, z-scores were estimated by subtracting the raw score from the predicted mean and then dividing this difference score by the root mean squared error term (RMSE) for a given linear regression model. Results: For each neuropsychological test, an estimated z-score was calculated for any raw score based on five different models that adjust for the demographic predictors of SEX, AGE and EDUCATION, either concurrently, individually or without covariates. The interactive online calculator allows the entry of a raw score and provides five corresponding estimated z-scores based on predictions from each corresponding linear regression model. The calculator produces percentile ranks and graphical output. Conclusions: An interactive, regression-based, normative score online calculator was created to serve as an additional resource for UDS clinical researchers, especially in guiding interpretation of individual performances that appear to fall in borderline realms and may be of particular utility for operationalizing subtle cognitive impairment present according to the newly proposed criteria for Stage 3 preclinical Alzheimer's disease.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/alzrt94en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308021/pdf/en_US
dash.licenseLAA
dc.subjectAlzheimer's diseaseen_US
dc.subjectcognitive agingen_US
dc.subjectmcien_US
dc.subjectmemoryen_US
dc.subjectnormsen_US
dc.titleA Web-Based Normative Calculator for the Uniform Data Set (UDS) Neuropsychological Test Batteryen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalAlzheimer's Research & Therapyen_US
dash.depositing.authorSherman, Janet Cohen
dc.date.available2012-05-10T18:07:28Z
dc.identifier.doi10.1186/alzrt94*
dash.authorsorderedfalse
dash.contributor.affiliatedSherman, Janet
dash.contributor.affiliatedMitchell, Meghan B
dash.contributor.affiliatedLocascio, Joseph
dash.contributor.affiliatedAtri, Alireza


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record