Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney

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Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney

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Title: Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney
Author: Duah, Mary; Staser, Karl; Valerius, Michael Todd; Hansard, Jennifer K.; Guo, Jin-jin; McMahon, Jill Ann; Vaughan, Joseph E.; Faria, Diane; Georgas, Kylie; Rumballe, Bree; Ren, Qun; Krautzberger, A. Michaela; Junker, Jan P.; Thiagarajan, Rathi D.; Machanick, Philip; Gray, Paul A.; van Oudenaarden, Alexander; Rowitch, David H.; Stiles, Charles Dean; Ma, Qiufu; Grimmond, Sean M.; Bailey, Timothy L.; Little, Melissa H.; McMahon, Andrew P.; Yu, Jing

Note: Order does not necessarily reflect citation order of authors.

Citation: Yu, Jing, Michael Todd Valerius, Mary Duah, Karl Staser, Jennifer K. Hansard, Jin-jin Guo, Jill Ann McMahon, et al. 2012. Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development 139(10): 1863-1873.
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Abstract: Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cell type-specific transcriptional programs; consequently, transcriptional regulatory factors are useful markers of emerging cellular complexity, and their expression patterns provide insights into the regulatory mechanisms at play. We performed a comprehensive genome-scale in situ expression screen of 921 transcriptional regulators in the developing mammalian urogenital system. Focusing on the kidney, analysis of regional-specific expression patterns identified novel markers and cell types associated with development and patterning of the urinary system. Furthermore, promoter analysis of synexpressed genes predicts transcriptional control mechanisms that regulate cell differentiation. The annotated informational resource (www.gudmap.org) will facilitate functional analysis of the mammalian kidney and provides useful information for the generation of novel genetic tools to manipulate emerging cell populations.
Published Version: doi:10.1242/dev.074005
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/22510988
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8730679

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  • FAS Scholarly Articles [7374]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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