Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney

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Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney

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dc.contributor.author Duah, Mary
dc.contributor.author Staser, Karl
dc.contributor.author Valerius, Michael Todd
dc.contributor.author Hansard, Jennifer K.
dc.contributor.author Guo, Jin-jin
dc.contributor.author McMahon, Jill Ann
dc.contributor.author Vaughan, Joseph E.
dc.contributor.author Faria, Diane
dc.contributor.author Georgas, Kylie
dc.contributor.author Rumballe, Bree
dc.contributor.author Ren, Qun
dc.contributor.author Krautzberger, A. Michaela
dc.contributor.author Junker, Jan P.
dc.contributor.author Thiagarajan, Rathi D.
dc.contributor.author Machanick, Philip
dc.contributor.author Gray, Paul A.
dc.contributor.author van Oudenaarden, Alexander
dc.contributor.author Rowitch, David H.
dc.contributor.author Stiles, Charles Dean
dc.contributor.author Ma, Qiufu
dc.contributor.author Grimmond, Sean M.
dc.contributor.author Bailey, Timothy L.
dc.contributor.author Little, Melissa H.
dc.contributor.author McMahon, Andrew P.
dc.contributor.author Yu, Jing
dc.date.accessioned 2012-05-11T19:42:05Z
dc.date.issued 2012
dc.identifier.citation Yu, Jing, Michael Todd Valerius, Mary Duah, Karl Staser, Jennifer K. Hansard, Jin-jin Guo, Jill Ann McMahon, et al. 2012. Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development 139(10): 1863-1873. en_US
dc.identifier.issn 0950-1991 en_US
dc.identifier.issn 1477-9129 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8730679
dc.description.abstract Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cell type-specific transcriptional programs; consequently, transcriptional regulatory factors are useful markers of emerging cellular complexity, and their expression patterns provide insights into the regulatory mechanisms at play. We performed a comprehensive genome-scale in situ expression screen of 921 transcriptional regulators in the developing mammalian urogenital system. Focusing on the kidney, analysis of regional-specific expression patterns identified novel markers and cell types associated with development and patterning of the urinary system. Furthermore, promoter analysis of synexpressed genes predicts transcriptional control mechanisms that regulate cell differentiation. The annotated informational resource (www.gudmap.org) will facilitate functional analysis of the mammalian kidney and provides useful information for the generation of novel genetic tools to manipulate emerging cell populations. en_US
dc.description.sponsorship Stem Cell and Regenerative Biology en_US
dc.language.iso en_US en_US
dc.publisher Company of Biologists en_US
dc.relation.isversionof doi:10.1242/dev.074005 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pubmed/22510988 en_US
dash.license OAP
dc.subject genome-scale expression screen en_US
dc.subject transcriptional regulator en_US
dc.subject kidney en_US
dc.subject mouse en_US
dc.title Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney en_US
dc.type Journal Article en_US
dc.description.version Author's Original en_US
dc.relation.journal Development en_US
dash.depositing.author McMahon, Andrew P.
dc.date.available 2012-05-11T19:42:05Z
dash.affiliation.other Department of Neurobiology en_US

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  • FAS Scholarly Articles [7374]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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