Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis
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Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis
| Title: | Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis |
| Author: |
Jacobsen, Eric N.; Birrell, James Andrew; Desrosiers, Jean-Nicolas
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Birrell, James A., Jean-Nicolas Desrosiers, and Eric N. Jacobsen. 2011. Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis. Journal of the American Chemical Society 133(35): 13872 -13875. |
| Full Text & Related Files: |
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| Abstract: | A highly-enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful \(\alpha\), \(\alpha\)-disubstituted butyrolactone products. This reaction is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride. |
| Published Version: | doi:10.1021/ja205602j |
| Terms of Use: | This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8737992 |
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Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
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