Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis

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Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis

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Title: Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis
Author: Jacobsen, Eric N.; Birrell, James Andrew; Desrosiers, Jean-Nicolas

Note: Order does not necessarily reflect citation order of authors.

Citation: Birrell, James A., Jean-Nicolas Desrosiers, and Eric N. Jacobsen. 2011. Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis. Journal of the American Chemical Society 133(35): 13872 -13875.
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Abstract: A highly-enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful \(\alpha\), \(\alpha\)-disubstituted butyrolactone products. This reaction is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride.
Published Version: doi:10.1021/ja205602j
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8737992

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  • FAS Scholarly Articles [7450]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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