Dual Catalysis in Enantioselective Oxidopyrylium-Based [5+2] Cycloadditions

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Dual Catalysis in Enantioselective Oxidopyrylium-Based [5+2] Cycloadditions

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Title: Dual Catalysis in Enantioselective Oxidopyrylium-Based [5+2] Cycloadditions
Author: Jacobsen, Eric N.; Burns, Noah; Witten, Michael R

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Citation: Burns, Noah Z., Michael R. Witten, and Eric N. Jacobsen. 2011. Dual catalysis in enantioselective oxidopyrylium-based [5 + 2] cycloadditions. Journal of the American Chemical Society 133(37): 14578–14581.
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Abstract: A new method is reported for effecting catalytic enantioselective intramolecular [5+2] cycloadditions based on oxidopyrylium intermediates. The dual catalyst system consists of a chiral primary aminothiourea and a second achiral thiourea. Experimental evidence points to a new type of cooperative catalysis with each species being necessary to generate a reactive pyrylium ion pair which undergoes subsequent cycloaddition with high enantioselectivity.
Published Version: doi:10.1021/ja206997e
Other Sources: https://www.ncbi.nlm.nih.gov/pubmed/21848300
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8737994

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  • FAS Scholarly Articles [6885]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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