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Title:	Dual Catalysis in Enantioselective Oxidopyrylium-Based [5+2] Cycloadditions
Author:	Jacobsen, Eric N.; Burns, Noah; Witten, Michael R Note: Order does not necessarily reflect citation order of authors.
Citation:	Burns, Noah Z., Michael R. Witten, and Eric N. Jacobsen. 2011. Dual catalysis in enantioselective oxidopyrylium-based [5 + 2] cycloadditions. Journal of the American Chemical Society 133(37): 14578–14581.
Full Text & Related Files:	42924693.pdf (609.9Kb; PDF)
Abstract:	A new method is reported for effecting catalytic enantioselective intramolecular [5+2] cycloadditions based on oxidopyrylium intermediates. The dual catalyst system consists of a chiral primary aminothiourea and a second achiral thiourea. Experimental evidence points to a new type of cooperative catalysis with each species being necessary to generate a reactive pyrylium ion pair which undergoes subsequent cycloaddition with high enantioselectivity.
Published Version:	doi:10.1021/ja206997e
Other Sources:	https://www.ncbi.nlm.nih.gov/pubmed/21848300
Terms of Use:	This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page:	http://nrs.harvard.edu/urn-3:HUL.InstRepos:8737994

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  Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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