Thiourea-Catalyzed Enantioselective Iso-Pictet-Spengler Reactions
| Title: | Thiourea-Catalyzed Enantioselective Iso-Pictet-Spengler Reactions |
| Author: |
Lee, Yunmi; Klausen, Rebekka S.; Jacobsen, Eric N.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Lee, Yunmi, Rebekka S. Klausen, and Eric N. Jacobsen. 2011. Thiourea-catalyzed enantioselective Iso-Pictet Spengler reactions. Organic Letters 13(20): 5564-5567. |
| Full Text & Related Files: |
21051065.pdf (605.4Kb; PDF) 
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| Abstract: | A one-pot condensation of isotryptamines and aldehydes that affords enantiomerically enriched 4-substituted tetrahydro-\(\gamma\)-carbolines is reported. The reaction is induced by a chiral thiourea/benzoic acid dual catalyst system. Purification of the N-Boc-protected products by trituration or crystallization provides the optically pure tetrahydro-\(\gamma\)-carboline derivatives in a scalable and highly practical procedure. |
| Published Version: | doi:10.1021/ol202300t |
| Other Sources: | https://www.ncbi.nlm.nih.gov/pubmed/21919478 |
| Terms of Use: | This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8737995 |
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