Mining the Web for Medical Hypothesis: A Proof-of-Concept System

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Mining the Web for Medical Hypothesis: A Proof-of-Concept System

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dc.contributor.author Maclean, Diana
dc.contributor.author Seltzer, Margo I.
dc.date.accessioned 2012-05-14T19:04:48Z
dc.date.issued 2012-05-14
dc.identifier.citation MacLean, Diana and Margo Seltzer. Forthcoming. Mining the Web for medical hypotheses: A proof-of-concept system. In Proceedings of the 2011 International Conference on Health Informatics (HEALTHINF'11), January 26 to 29, 2011, Rome, Italy. en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8739094
dc.description.abstract As the prevalence of blogs, discussion forums, and online news services continues to grow, so too does the portion of this Web content that relates to health and medicine. We propose that everyday, medically-oriented Web content is a valuable and viable data source for medical hypothesis generation and testing, despite its being noisy. In this paper, we present a proof-of-concept system supporting this notion. We construct a corpus comprising news articles relating to the drugs Vioxx, Naproxen and Ibuprofen, that were published between 1998-2002. Using this corpus, we show that there was a significant link between Vioxx and the concept “Myocardial Infarction” well before the drug was withdrawn from the market in 2004. Indeed, within the Vioxx-related content, the concept ranks amongst the top 3.3% in terms of importance. When compared with the Naproxen and Ibuprofen control literatures, the term occurs significantly more frequently in the Vioxx-related content. en_US
dc.description.sponsorship Engineering and Applied Sciences en_US
dc.language.iso en_US en_US
dc.relation.hasversion http://www.eecs.harvard.edu/margo/papers/healthinf11/paper.pdf en_US
dash.license OAP
dc.subject data mining en_US
dc.subject knowledge discovery en_US
dc.subject Vioxx en_US
dc.subject myocardial infarction en_US
dc.subject UMLS en_US
dc.subject MetaMap en_US
dc.title Mining the Web for Medical Hypothesis: A Proof-of-Concept System en_US
dc.type Monograph or Book en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Proceedings of the 2011 International Conference on Health Informatics en_US
dash.depositing.author Seltzer, Margo I.
dc.date.available 2012-05-14T19:04:48Z

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  • FAS Scholarly Articles [7289]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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