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dc.contributor.authorMaclean, Diana
dc.contributor.authorSeltzer, Margo I.
dc.date.accessioned2012-05-14T19:04:48Z
dc.date.issued2012-05-14
dc.identifier.citationMacLean, Diana and Margo Seltzer. Forthcoming. Mining the Web for medical hypotheses: A proof-of-concept system. In Proceedings of the 2011 International Conference on Health Informatics (HEALTHINF'11), January 26 to 29, 2011, Rome, Italy.en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8739094
dc.description.abstractAs the prevalence of blogs, discussion forums, and online news services continues to grow, so too does the portion of this Web content that relates to health and medicine. We propose that everyday, medically-oriented Web content is a valuable and viable data source for medical hypothesis generation and testing, despite its being noisy. In this paper, we present a proof-of-concept system supporting this notion. We construct a corpus comprising news articles relating to the drugs Vioxx, Naproxen and Ibuprofen, that were published between 1998-2002. Using this corpus, we show that there was a significant link between Vioxx and the concept “Myocardial Infarction” well before the drug was withdrawn from the market in 2004. Indeed, within the Vioxx-related content, the concept ranks amongst the top 3.3% in terms of importance. When compared with the Naproxen and Ibuprofen control literatures, the term occurs significantly more frequently in the Vioxx-related content.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.relation.hasversionhttp://www.eecs.harvard.edu/margo/papers/healthinf11/paper.pdfen_US
dash.licenseOAP
dc.subjectdata miningen_US
dc.subjectknowledge discoveryen_US
dc.subjectVioxxen_US
dc.subjectmyocardial infarctionen_US
dc.subjectUMLSen_US
dc.subjectMetaMapen_US
dc.titleMining the Web for Medical Hypothesis: A Proof-of-Concept Systemen_US
dc.typeMonograph or Booken_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalProceedings of the 2011 International Conference on Health Informaticsen_US
dash.depositing.authorSeltzer, Margo I.
dc.date.available2012-05-14T19:04:48Z
dash.authorsorderedfalse
dash.contributor.affiliatedSeltzer, Margo


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