Evaluating the Viscoelastic Properties of Tissue from Laser Speckle Fluctuations

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Evaluating the Viscoelastic Properties of Tissue from Laser Speckle Fluctuations

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Title: Evaluating the Viscoelastic Properties of Tissue from Laser Speckle Fluctuations
Author: Hajjarian, Zeinab; Nadkarni, Seemantini

Note: Order does not necessarily reflect citation order of authors.

Citation: Hajjarian, Zeinab, and Seemantini K. Nadkarni. 2012. Evaluating the viscoelastic properties of tissue from laser speckle fluctuations. Scientific Reports 2:316.
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Abstract: Most pathological conditions such as atherosclerosis, cancer, neurodegenerative, and orthopedic disorders are accompanied with alterations in tissue viscoelasticity. Laser Speckle Rheology (LSR) is a novel optical technology that provides the invaluable potential for mechanical assessment of tissue in situ. In LSR, the specimen is illuminated with coherent light and the time constant of speckle fluctuations, τ, is measured using a high speed camera. Prior work indicates that τ is closely correlated with tissue microstructure and composition. Here, we investigate the relationship between LSR measurements of τ and sample mechanical properties defined by the viscoelastic modulus, G*. Phantoms and tissue samples over a broad range of viscoelastic properties are evaluated using LSR and conventional mechanical testing. Results demonstrate a strong correlation between τ and |G*| for both phantom (r = 0.79, p <0.0001) and tissue (r = 0.88, p<0.0001) specimens, establishing the unique capability of LSR in characterizing tissue viscoelasticity.
Published Version: doi:10.1038/srep00316
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306019/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8796675

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