The Molecular Clockwork of a Protein-Based Circadian Oscillator

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The Molecular Clockwork of a Protein-Based Circadian Oscillator

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Title: The Molecular Clockwork of a Protein-Based Circadian Oscillator
Author: O'Shea, Erin K; Markson, Joseph Scott

Note: Order does not necessarily reflect citation order of authors.

Citation: Markson, Joseph Scott and Erin K. O'Shea. The molecular clockwork of a protein-based circadian oscillator. FEBS Letters 583(24): 3938-3947.
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Abstract: The circadian clock of the cyanobacterium Synechococcuselongatus PCC 7942 is governed by a core oscillator consisting of the proteins KaiA, KaiB, and KaiC. Remarkably, circadian oscillations in the phosphorylation state of KaiC can be reconstituted in a test tube by mixing the three Kai proteins and adenosine triphosphate. The in vitro oscillator provides a well-defined system in which experiments can be combined with mathematical analysis to understand the mechanism of a highly robust biological oscillator. In this Review, we summarize the biochemistry of the Kai proteins and examine models that have been proposed to explain how oscillations emerge from the properties of the oscillator’s constituents.
Published Version: doi:10.1016/j.febslet.2009.11.021
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
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  • FAS Scholarly Articles [8326]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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