Oscillations in Supercoiling Drive Circadian Gene Expression in Cyanobacteria

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Oscillations in Supercoiling Drive Circadian Gene Expression in Cyanobacteria

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Title: Oscillations in Supercoiling Drive Circadian Gene Expression in Cyanobacteria
Author: O'Shea, Erin K; Zuzow, Rick; Vijayan, Vikram

Note: Order does not necessarily reflect citation order of authors.

Citation: Vijayan, Vikram, Rick Zuzow, and Erin K. O'Shea. 2009. Oscillations in supercoiling drive circadian gene expression in cyanobacteria. Proceedings of the National Academy of Sciences 106(52): 22564-22568.
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Abstract: The cyanobacterium Synechococcus elongatus PCC 7942 exhibits oscillations in mRNA transcript abundance with 24-h periodicity under continuous light conditions. The mechanism underlying these oscillations remains elusive—neither cis nor trans-factors controlling circadian gene expression phase have been identified. Here, we show that the topological status of the chromosome is highly correlated with circadian gene expression state. We also demonstrate that DNA sequence characteristics of genes that appear monotonically activated and monotonically repressed by chromosomal relaxation during the circadian cycle are similar to those of supercoiling-responsive genes in Escherichia coli. Furthermore, perturbation of superhelical status within the physiological range elicits global changes in gene expression similar to those that occur during the normal circadian cycle.
Published Version: doi:10.1073/pnas.0912673106
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8841744

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  • FAS Scholarly Articles [7495]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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