Games in Tetrads: Segregation, Recombination, and Meiotic Drive

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Games in Tetrads: Segregation, Recombination, and Meiotic Drive

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dc.contributor.author Haig, David Addison
dc.date.accessioned 2012-06-29T21:04:28Z
dc.date.issued 2010
dc.identifier.citation Haig, David Addison. 2010. Games in tetrads: Segregation, recombination, and meiotic drive. The American Naturalist 176(4): 404-413. en_US
dc.identifier.issn 0003-0147 en_US
dc.identifier.issn 1537-5323 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8944745
dc.description.abstract The two alleles at a heterozygous locus segregate during meiosis, sometimes at meiosis I and sometimes at meiosis II. The timing of segregation is determined by the pattern of crossing‐over between a locus and its attached centromeres. Genes near centromeres can exploit this process by driving against spores from which the genes separated at meiosis I. Other genes, located distal to centromeres, can benefit from driving against spores from which they separated at meiosis II. Asymmetric female meiosis is particularly susceptible to such forms of drive. Selection on modifiers of recombination favors changes in the location of chiasmata that increase the proportion of tetrads of high average fitness by changing the timing of segregation. Such changes increase the frequency of driving alleles. This source of selection on recombination does not depend on effects on linkage disequilibrium. Recombinational responses to meiotic drive may contribute to sex differences in overall recombination and sex differences in the localization of chiasmata. en_US
dc.description.sponsorship Organismic and Evolutionary Biology en_US
dc.language.iso en_US en_US
dc.publisher University of Chicago Press en_US
dc.relation.isversionof doi:10.1086/656265 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pubmed/20726770 en_US
dash.license LAA
dc.subject meiosis en_US
dc.subject meiotic drive en_US
dc.subject polar body en_US
dc.subject recombination en_US
dc.subject centromere en_US
dc.subject segregation en_US
dc.title Games in Tetrads: Segregation, Recombination, and Meiotic Drive en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal The American Naturalist en_US
dash.depositing.author Haig, David Addison
dc.date.available 2012-06-29T21:04:28Z

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  • FAS Scholarly Articles [7362]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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