Regulation of the Final Stage of Mitosis by Components of the Pre-Replicative Complex and a Polo Kinase

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Regulation of the Final Stage of Mitosis by Components of the Pre-Replicative Complex and a Polo Kinase

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Title: Regulation of the Final Stage of Mitosis by Components of the Pre-Replicative Complex and a Polo Kinase
Author: Yim, Hyungshin; Erikson, Raymond Leo

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Citation: Yim, Hyungshin, and Raymond Leo Erikson. 2011. Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase. Cell Cycle 10(9): 1374-1377.
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Abstract: The accurate division of duplicated DNA is essential for maintenance of genomic stability in proliferating eukaryotic cells. Errors in DNA replication and chromosomal segregation may lead to cell death or genomic mutations that lead to oncogenic properties. Thus, tight regulation of DNA replication and mitosis is essential for maintaining genomic integrity. Cell division cycle 6 (Cdc6) is an essential factor for initiating DNA replication. Recent work shows that phosphorylation of Cdc6 by polo-like kinase 1 (Plk1), one of the essential mitotic kinases, regulates mitotic exit mediated by Cdk1 and separase. Here we discuss how pre-replicative complex factors are connected with Plk1 and affect mitotic exit.
Published Version: doi:10.4161/cc.10.9.15489
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/21519187
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8965559

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  • FAS Scholarly Articles [7470]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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