Optogenetics and Computer Vision for C. elegans Neuroscience and Other Biophysical Applications

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Title:	Optogenetics and Computer Vision for C. elegans Neuroscience and Other Biophysical Applications
Author:	Leifer, Andrew
Full Text & Related Files:	Leifer_gsas.harvard_0084L_10388.pdf (16.55Mb; PDF)
Abstract:	This work presents optogenetics and real-time computer vision techniques to non-invasively manipulate and monitor neural activity with high spatiotemporal resolution in awake behaving Caenorhabditis elegans. These methods were employed to dissect the nematode's mechanosensory and motor circuits and to elucidate the neural control of wave propagation during forward locomotion. Additionally, similar computer vision methods were used to automatically detect and decode fluorescing DNA origami nanobarcodes, a new class of fluorescent reporter constructs.
Terms of Use:	This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page:	http://nrs.harvard.edu/urn-3:HUL.InstRepos:9276708