# Mst1/2 Signalling to Yap: Gatekeeper for Liver Size and Tumour Development

 Title: Mst1/2 Signalling to Yap: Gatekeeper for Liver Size and Tumour Development Author: Bardeesy, N; Avruch, Joseph; Zhou, D; Fitamant, Julien Note: Order does not necessarily reflect citation order of authors. Citation: Avruch, J, D Zhou, J Fitamant, and N Bardeesy. 2011. Mst1/2 signalling to yap: Gatekeeper for liver size and tumour development. British Journal of Cancer 104(1): 24-32. Full Text & Related Files: 3039822.pdf (676.1Kb; PDF) Abstract: The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation that could lead to cancer. Regulation of liver size is of particular interest inasmuch as this organ maintains the capacity for regeneration throughout life, and is able to regain precisely its original mass after partial surgical resection. Recent studies using genetically engineered mouse strains have shed new light on this problem; the Hippo signalling pathway, first elucidated as a regulator of organ size in $$Drosophila$$, has been identified as dominant determinant of liver growth. Defects in this pathway in mouse liver lead to sustained liver overgrowth and the eventual development of both major types of liver cancer, hepatocellular carcinoma and cholangiocarcinoma. In this review, we discuss the role of Hippo signalling in liver biology and the contribution of this pathway to liver cancer in humans. Published Version: doi:10.1038/sj.bjc.6606011 Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039822/pdf/ Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:9369409 Downloads of this work: