Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

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Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

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Title: Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals
Author: Brainard, Diana M.; Rathod, Almas; Piechocka-Trocha, Alicja; Fideli, Ulgen; Mulenga, Joseph; Shutes, Erin; Alvino, Donna Marie L.; Hunter, Eric; Allen, Susan A.; Addo, Marylyn Martina; Altfeld, Marcus; Walker, Bruce David

Note: Order does not necessarily reflect citation order of authors.

Citation: Addo, Marylyn M., Marcus Altfeld, Diana M. Brainard, Almas Rathod, Alicja Piechocka-Trocha, Ulgen Fideli, Joseph Mulenga, et al. 2011. Lack of detectable HIV-1–specific CD8+ T cell responses in Zambian HIV-1–exposed seronegative partners of HIV-1–positive individuals. Journal of Infectious Diseases 203(2): 258-262.
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Abstract: Human immunodeficiency virus type 1 (HIV-1)–specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1–specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1–specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1–specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.
Published Version: doi:10.1093/infdis/jiq028
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071055/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:9369410

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