Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

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Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

dc.contributor.author	Brainard, Diana M.
dc.contributor.author	Rathod, Almas
dc.contributor.author	Piechocka-Trocha, Alicja
dc.contributor.author	Fideli, Ulgen
dc.contributor.author	Mulenga, Joseph
dc.contributor.author	Shutes, Erin
dc.contributor.author	Alvino, Donna Marie L.
dc.contributor.author	Hunter, Eric
dc.contributor.author	Allen, Susan A.
dc.contributor.author	Addo, Marylyn Martina
dc.contributor.author	Altfeld, Marcus
dc.contributor.author	Walker, Bruce David
dc.date.accessioned	2012-08-08T13:25:13Z
dc.date.issued	2011
dc.identifier.citation	Addo, Marylyn M., Marcus Altfeld, Diana M. Brainard, Almas Rathod, Alicja Piechocka-Trocha, Ulgen Fideli, Joseph Mulenga, et al. 2011. Lack of detectable HIV-1–specific CD8+ T cell responses in Zambian HIV-1–exposed seronegative partners of HIV-1–positive individuals. Journal of Infectious Diseases 203(2): 258-262.	en_US
dc.identifier.issn	0022-1899	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:9369410
dc.description.abstract	Human immunodeficiency virus type 1 (HIV-1)–specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1–specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1–specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1–specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Oxford University Press	en_US
dc.relation.isversionof	doi:10.1093/infdis/jiq028	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071055/pdf/	en_US
dash.license	LAA
dc.subject	HIV/AIDS	en_US
dc.title	Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	Journal of Infectious Diseases	en_US
dash.depositing.author	Addo, Marylyn Martina
dc.date.available	2012-08-08T13:25:13Z