Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

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Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals

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dc.contributor.author Brainard, Diana M.
dc.contributor.author Rathod, Almas
dc.contributor.author Piechocka-Trocha, Alicja
dc.contributor.author Fideli, Ulgen
dc.contributor.author Mulenga, Joseph
dc.contributor.author Shutes, Erin
dc.contributor.author Alvino, Donna Marie L.
dc.contributor.author Hunter, Eric
dc.contributor.author Allen, Susan A.
dc.contributor.author Addo, Marylyn Martina
dc.contributor.author Altfeld, Marcus
dc.contributor.author Walker, Bruce David
dc.date.accessioned 2012-08-08T13:25:13Z
dc.date.issued 2011
dc.identifier.citation Addo, Marylyn M., Marcus Altfeld, Diana M. Brainard, Almas Rathod, Alicja Piechocka-Trocha, Ulgen Fideli, Joseph Mulenga, et al. 2011. Lack of detectable HIV-1–specific CD8+ T cell responses in Zambian HIV-1–exposed seronegative partners of HIV-1–positive individuals. Journal of Infectious Diseases 203(2): 258-262. en_US
dc.identifier.issn 0022-1899 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9369410
dc.description.abstract Human immunodeficiency virus type 1 (HIV-1)–specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1–specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1–specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1–specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals. en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.relation.isversionof doi:10.1093/infdis/jiq028 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071055/pdf/ en_US
dash.license LAA
dc.subject HIV/AIDS en_US
dc.title Lack of Detectable HIV-1–Specific CD8+ T Cell Responses in Zambian HIV-1–Exposed Seronegative Partners of HIV-1–Positive Individuals en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Infectious Diseases en_US
dash.depositing.author Addo, Marylyn Martina
dc.date.available 2012-08-08T13:25:13Z

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