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dc.contributor.authorKilpeläinen, T. O.
dc.contributor.authorSekine, A.
dc.contributor.authorYajnik, C. S.
dc.contributor.authorTakeuchi, F.
dc.contributor.authorYamamoto, K.
dc.contributor.authorMani, K. R.
dc.contributor.authorBeen, L. F.
dc.contributor.authorImamura, M.
dc.contributor.authorNakashima, E.
dc.contributor.authorFujisawa, T.
dc.contributor.authorKarasawa, S.
dc.contributor.authorJoglekar, C. V.
dc.contributor.authorFall, C. H. D.
dc.contributor.authorSham, P. C.
dc.contributor.authorShu, X.
dc.contributor.authorDeng, H.
dc.contributor.authorIkegami, H.
dc.contributor.authorKrishnaveni, G. V.
dc.contributor.authorSanghera, D. K.
dc.contributor.authorChuang, L.
dc.contributor.authorDaimon, M.
dc.contributor.authorHotta, K.
dc.contributor.authorKooner, J. S.
dc.contributor.authorChandak, G. R.
dc.contributor.authorMaeda, S.
dc.contributor.authorDorajoo, R.
dc.contributor.authorYokota, M.
dc.contributor.authorTakayanagi, R.
dc.contributor.authorLoos, R. J. F.
dc.contributor.authorSong, Yiqing
dc.contributor.authorLi, H.
dc.contributor.authorLiu, C.
dc.contributor.authorZhu, J.
dc.contributor.authorLiu, Y.
dc.contributor.authorHu, C.
dc.contributor.authorYang, Z.
dc.contributor.authorZhang, W.
dc.contributor.authorBao, W.
dc.contributor.authorCha, S.
dc.contributor.authorWu, Y.
dc.contributor.authorYang, T.
dc.contributor.authorChoi, B. Y.
dc.contributor.authorZhou, D.
dc.contributor.authorChan, J. C.
dc.contributor.authorLee, N.
dc.contributor.authorWen, W.
dc.contributor.authorLu, W.
dc.contributor.authorChang, Y.
dc.contributor.authorXiang, Y.
dc.contributor.authorGao, Y.
dc.contributor.authorLiu, S.
dc.contributor.authorSong, Yiqing
dc.contributor.authorKwak, S. H.
dc.contributor.authorShin, H. D.
dc.contributor.authorPark, K. S.
dc.contributor.authorKim, J. Y.
dc.contributor.authorLam, K. S. L.
dc.contributor.authorZheng, W.
dc.contributor.authorLiu, L.
dc.contributor.authorHu, R.
dc.contributor.authorKim, Y.
dc.contributor.authorJia, W.
dc.contributor.authorChambers, J. C.
dc.contributor.authorMa, R. C.
dc.contributor.authorKato, N.
dc.contributor.authorLin, X.
dc.date.accessioned2012-08-10T17:56:52Z
dc.date.issued2012
dc.identifier.citationLi, H., T. O. Kilpeläinen, C. Liu, J. Zhu, Y. Liu, C. Hu, Z. Yang, et al. 2012. Association of genetic variation in \(FTO\) with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia 55(4): 981-995.en_US
dc.identifier.issn0012-186Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9393249
dc.description.abstractAims/hypothesis: \(FTO\) harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for \(FTO\) in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the \(FTO\) locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians. Methods: All studies published on the association between \(FTO\)-rs9939609 (or proxy [r\(^2\) > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes. Results: The \(FTO\)-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 × 10\(^{−19}\)), overweight by 1.13-fold/allele (p = 1.0 × 10\(^{−11}\)) and type 2 diabetes by 1.15-fold/allele (p = 5.5 × 10\(^{−8}\)). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 × 10\(^{−5}\)). The \(FTO\)-rs9939609 minor allele increased BMI by 0.26 kg/m2 per allele (p = 2.8 × 10\(^{−17}\)), WHR by 0.003/allele (p = 1.2 × 10\(^{−6}\)), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12–20%) than South Asians (30–33%), the effect of \(FTO\) variation on obesity-related traits and type 2 diabetes was similar in the two populations. Conclusions/interpretation: \(FTO\) is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, \(FTO\) is also associated with type 2 diabetes independently of BMI. Electronic supplementary material The online version of this article (doi:10.1007/s00125-011-2370-7) contains peer-reviewed but unedited supplementary material, which is available to authorised users.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofdoi:10.1007/s00125-011-2370-7en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296006/pdf/en_US
dash.licenseLAA
dc.subjectAsiansen_US
dc.subjectFTOen_US
dc.subjectmeta-analysisen_US
dc.subjectobesityen_US
dc.subjecttype 2 diabetesen_US
dc.titleAssociation of Genetic Variation in \(FTO\) with Risk of Obesity and Type 2 Diabetes with Data from 96,551 East and South Asiansen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetologiaen_US
dash.depositing.authorSong, Yiqing
dc.date.available2012-08-10T17:56:52Z
dc.identifier.doi10.1007/s00125-011-2370-7*
dash.authorsorderedfalse
dash.contributor.affiliatedSong, Yiqing
dash.contributor.affiliatedSong, Yiqing


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