dc.contributor.author | Kilpeläinen, T. O. | |
dc.contributor.author | Sekine, A. | |
dc.contributor.author | Yajnik, C. S. | |
dc.contributor.author | Takeuchi, F. | |
dc.contributor.author | Yamamoto, K. | |
dc.contributor.author | Mani, K. R. | |
dc.contributor.author | Been, L. F. | |
dc.contributor.author | Imamura, M. | |
dc.contributor.author | Nakashima, E. | |
dc.contributor.author | Fujisawa, T. | |
dc.contributor.author | Karasawa, S. | |
dc.contributor.author | Joglekar, C. V. | |
dc.contributor.author | Fall, C. H. D. | |
dc.contributor.author | Sham, P. C. | |
dc.contributor.author | Shu, X. | |
dc.contributor.author | Deng, H. | |
dc.contributor.author | Ikegami, H. | |
dc.contributor.author | Krishnaveni, G. V. | |
dc.contributor.author | Sanghera, D. K. | |
dc.contributor.author | Chuang, L. | |
dc.contributor.author | Daimon, M. | |
dc.contributor.author | Hotta, K. | |
dc.contributor.author | Kooner, J. S. | |
dc.contributor.author | Chandak, G. R. | |
dc.contributor.author | Maeda, S. | |
dc.contributor.author | Dorajoo, R. | |
dc.contributor.author | Yokota, M. | |
dc.contributor.author | Takayanagi, R. | |
dc.contributor.author | Loos, R. J. F. | |
dc.contributor.author | Song, Yiqing | |
dc.contributor.author | Li, H. | |
dc.contributor.author | Liu, C. | |
dc.contributor.author | Zhu, J. | |
dc.contributor.author | Liu, Y. | |
dc.contributor.author | Hu, C. | |
dc.contributor.author | Yang, Z. | |
dc.contributor.author | Zhang, W. | |
dc.contributor.author | Bao, W. | |
dc.contributor.author | Cha, S. | |
dc.contributor.author | Wu, Y. | |
dc.contributor.author | Yang, T. | |
dc.contributor.author | Choi, B. Y. | |
dc.contributor.author | Zhou, D. | |
dc.contributor.author | Chan, J. C. | |
dc.contributor.author | Lee, N. | |
dc.contributor.author | Wen, W. | |
dc.contributor.author | Lu, W. | |
dc.contributor.author | Chang, Y. | |
dc.contributor.author | Xiang, Y. | |
dc.contributor.author | Gao, Y. | |
dc.contributor.author | Liu, S. | |
dc.contributor.author | Song, Yiqing | |
dc.contributor.author | Kwak, S. H. | |
dc.contributor.author | Shin, H. D. | |
dc.contributor.author | Park, K. S. | |
dc.contributor.author | Kim, J. Y. | |
dc.contributor.author | Lam, K. S. L. | |
dc.contributor.author | Zheng, W. | |
dc.contributor.author | Liu, L. | |
dc.contributor.author | Hu, R. | |
dc.contributor.author | Kim, Y. | |
dc.contributor.author | Jia, W. | |
dc.contributor.author | Chambers, J. C. | |
dc.contributor.author | Ma, R. C. | |
dc.contributor.author | Kato, N. | |
dc.contributor.author | Lin, X. | |
dc.date.accessioned | 2012-08-10T17:56:52Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Li, H., T. O. Kilpeläinen, C. Liu, J. Zhu, Y. Liu, C. Hu, Z. Yang, et al. 2012. Association of genetic variation in \(FTO\) with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia 55(4): 981-995. | en_US |
dc.identifier.issn | 0012-186X | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:9393249 | |
dc.description.abstract | Aims/hypothesis: \(FTO\) harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for \(FTO\) in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the \(FTO\) locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians. Methods: All studies published on the association between \(FTO\)-rs9939609 (or proxy [r\(^2\) > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes. Results: The \(FTO\)-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 × 10\(^{−19}\)), overweight by 1.13-fold/allele (p = 1.0 × 10\(^{−11}\)) and type 2 diabetes by 1.15-fold/allele (p = 5.5 × 10\(^{−8}\)). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 × 10\(^{−5}\)). The \(FTO\)-rs9939609 minor allele increased BMI by 0.26 kg/m2 per allele (p = 2.8 × 10\(^{−17}\)), WHR by 0.003/allele (p = 1.2 × 10\(^{−6}\)), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12–20%) than South Asians (30–33%), the effect of \(FTO\) variation on obesity-related traits and type 2 diabetes was similar in the two populations. Conclusions/interpretation: \(FTO\) is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, \(FTO\) is also associated with type 2 diabetes independently of BMI. Electronic supplementary material The online version of this article (doi:10.1007/s00125-011-2370-7) contains peer-reviewed but unedited supplementary material, which is available to authorised users. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Springer-Verlag | en_US |
dc.relation.isversionof | doi:10.1007/s00125-011-2370-7 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296006/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Asians | en_US |
dc.subject | FTO | en_US |
dc.subject | meta-analysis | en_US |
dc.subject | obesity | en_US |
dc.subject | type 2 diabetes | en_US |
dc.title | Association of Genetic Variation in \(FTO\) with Risk of Obesity and Type 2 Diabetes with Data from 96,551 East and South Asians | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Diabetologia | en_US |
dash.depositing.author | Song, Yiqing | |
dc.date.available | 2012-08-10T17:56:52Z | |
dc.identifier.doi | 10.1007/s00125-011-2370-7 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Song, Yiqing | |
dash.contributor.affiliated | Song, Yiqing | |