African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts

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African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts

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dc.contributor.author Cheng, Ching-Yu
dc.contributor.author Haiman, Christopher A.
dc.contributor.author Patterson, Nick
dc.contributor.author Elizabeth, Selvin
dc.contributor.author Akylbekova, Ermeg L.
dc.contributor.author Brancati, Frederick L.
dc.contributor.author Coresh, Josef
dc.contributor.author Boerwinkle, Eric
dc.contributor.author Taylor, Herman A.
dc.contributor.author Henderson, Brian E.
dc.contributor.author Wilson, James G.
dc.contributor.author Reich, David Emil
dc.contributor.author Tandon, Arti
dc.contributor.author Altshuler, David Matthew
dc.contributor.author Kao, W. H. Linda
dc.date.accessioned 2012-08-10T18:17:01Z
dc.date.issued 2012
dc.identifier.citation Cheng, Ching-Yu, David Reich, Christopher A. Haiman, Arti Tandon, Nick Patterson, Selvin Elizabeth, Ermeg L. Akylbekova, et al. 2012. African ancestry and its correlation to type 2 diabetes in African Americans: A genetic admixture analysis in three U.S. population cohorts. PLoS ONE 7(3): e32840. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9393258
dc.description.abstract The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that genetic factors may explain some of this population difference in disease risk. However, relatively few genetic studies have examined this hypothesis in a large sample of African Americans with and without diabetes. Therefore, we performed an admixture analysis using 2,189 ancestry-informative markers in 7,021 African Americans (2,373 with type 2 diabetes and 4,648 without) from the Atherosclerosis Risk in Communities Study, the Jackson Heart Study, and the Multiethnic Cohort to 1) determine the association of type 2 diabetes and its related quantitative traits with African ancestry controlling for measures of SES and 2) identify genetic loci for type 2 diabetes through a genome-wide admixture mapping scan. The median percentage of African ancestry of diabetic participants was slightly greater than that of non-diabetic participants (study-adjusted difference = 1.6%, \(P\)<0.001). The odds ratio for diabetes comparing participants in the highest vs. lowest tertile of African ancestry was 1.33 (95% confidence interval 1.13–1.55), after adjustment for age, sex, study, body mass index (BMI), and SES. Admixture scans identified two potential loci for diabetes at 12p13.31 (LOD = 4.0) and 13q14.3 (Z score = 4.5, \(P\) = 6.6×10\(^{−6}\)). In conclusion, genetic ancestry has a significant association with type 2 diabetes above and beyond its association with non-genetic risk factors for type 2 diabetes in African Americans, but no single gene with a major effect is sufficient to explain a large portion of the observed population difference in risk of diabetes. There undoubtedly is a complex interplay among specific genetic loci and non-genetic factors, which may both be associated with overall admixture, leading to the observed ethnic differences in diabetes risk. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0032840 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306373/pdf/ en_US
dash.license LAA
dc.subject biology en_US
dc.subject genetics en_US
dc.subject heredity en_US
dc.subject human genetics en_US
dc.subject population genetics en_US
dc.subject medicine en_US
dc.subject endocrinology en_US
dc.subject diabetic endocrinology en_US
dc.subject epidemiology en_US
dc.subject nutrition en_US
dc.subject public health en_US
dc.title African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Reich, David Emil
dc.date.available 2012-08-10T18:17:01Z

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