Meta-Profiles of Gene Expression during Aging: Limited Similarities between Mouse and Human and an Unexpectedly Decreased Inflammatory Signature

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Meta-Profiles of Gene Expression during Aging: Limited Similarities between Mouse and Human and an Unexpectedly Decreased Inflammatory Signature

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dc.contributor.author Sun, Liou
dc.contributor.author Xing, Xianying
dc.contributor.author Fisher, Gary J.
dc.contributor.author Elder, James T.
dc.contributor.author Gudjonsson, Johann E.
dc.contributor.author Bulyk, Martha Leonia
dc.contributor.author Johnston, Andrew
dc.contributor.author Swindell, William R.
dc.date.accessioned 2012-09-10T18:05:33Z
dc.date.issued 2012
dc.identifier.citation Swindell, William R., Andrew Johnston, Liou Sun, Xianying Xing, Gary J. Fisher, Martha L. Bulyk, James T. Elder, and Johann E. Gudjonsson. 2012. Meta-profiles of gene expression during aging: Limited similarities between mouse and human and an unexpectedly decreased inflammatory signature. PLoS ONE 7(3): e33204. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9527628
dc.description.abstract Background: Skin aging is associated with intrinsic processes that compromise the structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood and conservation of these mechanisms between humans and mice is uncertain. Results: We used genome-wide expression profiling to investigate the aging skin transcriptome. In humans, age-related shifts in gene expression were sex-specific. In females, aging increased expression of transcripts associated with T-cells, B-cells and dendritic cells, and decreased expression of genes in regions with elevated Zeb1, AP-2 and YY1 motif density. In males, however, these effects were contrasting or absent. When age-associated gene expression patterns in human skin were compared to those in tail skin from CB6F1 mice, overall human-mouse correspondence was weak. Moreover, inflammatory gene expression patterns were not induced with aging of mouse tail skin, and well-known aging biomarkers were in fact decreased (e.g., Clec7a, Lyz1 and Lyz2). These unexpected patterns and weak human-mouse correspondence may be due to decreased abundance of antigen presenting cells in mouse tail skin with age. Conclusions: Aging is generally associated with a pro-inflammatory state, but we have identified an exception to this pattern with aging of CB6F1 mouse tail skin. Aging therefore does not uniformly heighten inflammatory status across all mouse tissues. Furthermore, we identified both intercellular and intracellular mechanisms of transcriptome aging, including those that are sex- and species-specific. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0033204 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296693/pdf/ en_US
dash.license LAA
dc.subject biology en_US
dc.subject anatomy and physiology en_US
dc.subject physiological processes en_US
dc.subject computational biology en_US
dc.subject genomics en_US
dc.subject model organisms en_US
dc.subject animal models en_US
dc.subject medicine en_US
dc.subject dermatology en_US
dc.title Meta-Profiles of Gene Expression during Aging: Limited Similarities between Mouse and Human and an Unexpectedly Decreased Inflammatory Signature en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Bulyk, Martha Leonia
dc.date.available 2012-09-10T18:05:33Z

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