Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles

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Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles

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dc.contributor.author Ho, Don N.
dc.contributor.author Kohler, Nathan
dc.contributor.author Sigdel, Aruna
dc.contributor.author Xu, Chenjie
dc.contributor.author Sun, Shouheng
dc.contributor.author Morgan, Jeffrey R.
dc.contributor.author Kalluri, Raghu
dc.date.accessioned 2012-10-09T00:29:10Z
dc.date.issued 2012
dc.identifier.citation Ho, Don N., Nathan Kohler, Aruna Sigdel, Raghu Kalluri, Jeffrey R. Morgan, Chenjie Xu, and Shouheng Sun. 2012. Penetration of endothelial cell coated multicellular tumor spheroids by iron oxide nanoparticles. Theranostics 2(1): 66-75. en_US
dc.identifier.issn 1838-7640 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9696329
dc.description.abstract Iron oxide nanoparticles are a useful diagnostic contrast agent and have great potential for therapeutic applications. Multiple emerging diagnostic and therapeutic applications and the numerous versatile parameters of the nanoparticle platform require a robust biological model for characterization and assessment. Here we investigate the use of iron oxide nanoparticles that target tumor vasculature, via the tumstatin peptide, in a novel three-dimensional tissue culture model. The developed tissue culture model more closely mimics the in vivo environment with a leaky endothelium coating around a glioma tumor mass. Tumstatin-iron oxide nanoparticles showed penetration and selective targeting to endothelial cell coating on the tumor in the three-dimensional model, and had approximately 2 times greater uptake in vitro and 2.7 times tumor neo-vascularization inhibition. Tumstatin provides targeting and therapeutic capabilities to the iron oxide nanoparticle diagnostic contrast agent platform. And the novel endothelial cell-coated tumor model provides an in vitro microtissue environment to evaluate nanoparticles without moving into costly and time-consuming animal models. en_US
dc.language.iso en_US en_US
dc.publisher Ivyspring International Publisher en_US
dc.relation.isversionof doi:10.7150/thno.3568 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263517/pdf/ en_US
dash.license LAA
dc.subject iron oxide nanoparticles en_US
dc.subject tumstatin en_US
dc.subject tumor penetration en_US
dc.subject multicellular tumor spheroids en_US
dc.subject theranostic en_US
dc.subject magnetic en_US
dc.subject nanoparticle en_US
dc.subject imaging en_US
dc.subject drug delivery en_US
dc.subject anti-angiogenesis en_US
dc.title Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Theranostics en_US
dash.depositing.author Kalluri, Raghu
dc.date.available 2012-10-09T00:29:10Z

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