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dc.contributor.authorHo, Don N.
dc.contributor.authorKohler, Nathan
dc.contributor.authorSigdel, Aruna
dc.contributor.authorKalluri, Raghu
dc.contributor.authorMorgan, Jeffrey R.
dc.contributor.authorXu, Chenjie
dc.contributor.authorSun, Shouheng
dc.date.accessioned2012-10-09T00:29:10Z
dc.date.issued2012
dc.identifier.citationHo, Don N., Nathan Kohler, Aruna Sigdel, Raghu Kalluri, Jeffrey R. Morgan, Chenjie Xu, and Shouheng Sun. 2012. Penetration of endothelial cell coated multicellular tumor spheroids by iron oxide nanoparticles. Theranostics 2(1): 66-75.en_US
dc.identifier.issn1838-7640en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9696329
dc.description.abstractIron oxide nanoparticles are a useful diagnostic contrast agent and have great potential for therapeutic applications. Multiple emerging diagnostic and therapeutic applications and the numerous versatile parameters of the nanoparticle platform require a robust biological model for characterization and assessment. Here we investigate the use of iron oxide nanoparticles that target tumor vasculature, via the tumstatin peptide, in a novel three-dimensional tissue culture model. The developed tissue culture model more closely mimics the in vivo environment with a leaky endothelium coating around a glioma tumor mass. Tumstatin-iron oxide nanoparticles showed penetration and selective targeting to endothelial cell coating on the tumor in the three-dimensional model, and had approximately 2 times greater uptake in vitro and 2.7 times tumor neo-vascularization inhibition. Tumstatin provides targeting and therapeutic capabilities to the iron oxide nanoparticle diagnostic contrast agent platform. And the novel endothelial cell-coated tumor model provides an in vitro microtissue environment to evaluate nanoparticles without moving into costly and time-consuming animal models.en_US
dc.language.isoen_USen_US
dc.publisherIvyspring International Publisheren_US
dc.relation.isversionofdoi:10.7150/thno.3568en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263517/pdf/en_US
dash.licenseLAA
dc.subjectiron oxide nanoparticlesen_US
dc.subjecttumstatinen_US
dc.subjecttumor penetrationen_US
dc.subjectmulticellular tumor spheroidsen_US
dc.subjecttheranosticen_US
dc.subjectmagneticen_US
dc.subjectnanoparticleen_US
dc.subjectimagingen_US
dc.subjectdrug deliveryen_US
dc.subjectanti-angiogenesisen_US
dc.titlePenetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticlesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalTheranosticsen_US
dash.depositing.authorKalluri, Raghu
dc.date.available2012-10-09T00:29:10Z
dc.identifier.doi10.7150/thno.3568*
dash.contributor.affiliatedKalluri, Raghu


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