Magnetic Nanoparticles and MicroNMR for Diagnostic Applications

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Magnetic Nanoparticles and MicroNMR for Diagnostic Applications

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dc.contributor.author Shao, Huilin
dc.contributor.author Min, Changwook
dc.contributor.author Issadore, David Aaron
dc.contributor.author Liong, Monty
dc.contributor.author Yoon, Tae-Jong
dc.contributor.author Weissleder, Ralph
dc.contributor.author Lee, Hakho
dc.date.accessioned 2012-10-09T20:50:48Z
dc.date.issued 2012
dc.identifier.citation Shao, Huilin, Changwook Min, David Aaron Issadore, Monty Liong, Tae-Jong Yoon, Ralph Weissleder, and Hakho Lee. 2012. Magnetic nanoparticles and microNMR for diagnostic applications. Theranostics 2(1): 55-65. en_US
dc.identifier.issn 1838-7640 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9709720
dc.description.abstract Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy efficacy. Biosensing strategies using magnetic nanoparticles (MNPs) have recently received considerable attention, since they offer unique advantages over traditional detection methods. Specifically, because biological samples have negligible magnetic background, MNPs can be used to obtain highly sensitive measurements in minimally processed samples. This review focuses on the use of MNPs for in vitro detection of cellular biomarkers based on nuclear magnetic resonance (NMR) effects. This detection platform, termed diagnostic magnetic resonance (DMR), exploits MNPs as proximity sensors to modulate the spin-spin relaxation time of water molecules surrounding the molecularly-targeted nanoparticles. With new developments such as more effective MNP biosensors, advanced conjugational strategies, and highly sensitive miniaturized NMR systems, the DMR detection capabilities have been considerably improved. These developments have also enabled parallel and rapid measurements from small sample volumes and on a wide range of targets, including whole cells, proteins, DNA/mRNA, metabolites, drugs, viruses and bacteria. The DMR platform thus makes a robust and easy-to-use sensor system with broad applications in biomedicine, as well as clinical utility in point-of-care settings. en_US
dc.language.iso en_US en_US
dc.publisher Ivyspring International Publisher en_US
dc.relation.isversionof doi:10.7150/thno.3465 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263516/pdf/ en_US
dash.license LAA
dc.subject biosensor en_US
dc.subject diagnostics en_US
dc.subject magnetic nanoparticle en_US
dc.subject microfluidics en_US
dc.subject nuclear magnetic resonance en_US
dc.title Magnetic Nanoparticles and MicroNMR for Diagnostic Applications en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Theranostics en_US
dash.depositing.author Weissleder, Ralph
dc.date.available 2012-10-09T20:50:48Z

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