Association of Body Mass Index in Early Adulthood and Middle Age with Future Site-Specific Cancer Mortality: The Harvard Alumni Health Study

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Association of Body Mass Index in Early Adulthood and Middle Age with Future Site-Specific Cancer Mortality: The Harvard Alumni Health Study

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dc.contributor.author Batty, G. D.
dc.contributor.author Gray, L.
dc.contributor.author Lee, I-Min
dc.contributor.author Sesso, Howard David
dc.date.accessioned 2012-10-22T16:53:29Z
dc.date.issued 2012
dc.identifier.citation Gray, L., I-M. Lee, H. D. Sesso, and G. D. Batty. 2012. Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: The Harvard Alumni Health Study. Annals of Oncology 23(3): 754-759. en_US
dc.identifier.issn 0923-7534 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9793860
dc.description.abstract Background:: The association between adiposity in early adulthood and subsequent development of specific malignancies is unclear. Further, the potential for mediation by adiposity in middle age has not been well examined. In a rare study, we investigated the association of body mass index (BMI) in early adulthood with mortality from several site-specific cancers. Design: In the Harvard Alumni Health Study cohort, 19 593 males had a physical examination at the university between 1914 and 1952 (mean age: 18.4 years) and returned a questionnaire in 1962 or 1966 (mean age = 45.1 years). BMI was computed using weight (kg)/\(height^2\) (\(m^2\)) at both time points. Vital status follow up continued for a maximum of 82 years. Results: Positive early adulthood cancer mortality gradients by BMI were found for all malignancies combined (adjusted hazard ratio [HR] = 1.11; 95% confidence interval [CI]: 1.05–1.17 for a one standard deviation increase in early adulthood BMI), and for lung (HR = 1.24; 95% CI = 1.10–1.40) and skin (HR = 1.29; 95% CI = 0.96–1.75) cancers. There were also apparent associations for cancers of the oesophagus and urogenital sites. Mediation by BMI in middle age was found to be minimal. Conclusion: Higher BMI in early adulthood appears to be a direct risk factor for selected malignancies several decades later. en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.relation.isversionof doi:10.1093/annonc/mdr270 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331729/pdf/ en_US
dash.license LAA
dc.subject epidemiology en_US
dc.subject body mass index en_US
dc.subject Harvard en_US
dc.subject cohort study en_US
dc.subject mortality en_US
dc.title Association of Body Mass Index in Early Adulthood and Middle Age with Future Site-Specific Cancer Mortality: The Harvard Alumni Health Study en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Annals of Oncology en_US
dash.depositing.author Sesso, Howard David
dc.date.available 2012-10-22T16:53:29Z

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