Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

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Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

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dc.contributor.author Pattaro, Cristian
dc.contributor.author Köttgen, Anna
dc.contributor.author Teumer, Alexander
dc.contributor.author Böger, Carsten A.
dc.contributor.author Fuchsberger, Christian
dc.contributor.author Olden, Matthias
dc.contributor.author Chen, Ming-Huei
dc.contributor.author Tin, Adrienne
dc.contributor.author Taliun, Daniel
dc.contributor.author Li, Man
dc.contributor.author Gao, Xiaoyi
dc.contributor.author Gorski, Mathias
dc.contributor.author Yang, Qiong
dc.contributor.author Hundertmark, Claudia
dc.contributor.author Foster, Meredith C.
dc.contributor.author Glazer, Nicole
dc.contributor.author Isaacs, Aaron
dc.contributor.author Liu, Ching-Ti
dc.contributor.author Smith, Albert V.
dc.contributor.author O'Connell, Jeffrey R.
dc.contributor.author Struchalin, Maksim
dc.contributor.author Tanaka, Toshiko
dc.contributor.author Gierman, Hinco J.
dc.contributor.author Feitosa, Mary
dc.contributor.author Hwang, Shih-Jen
dc.contributor.author Atkinson, Elizabeth J.
dc.contributor.author Lohman, Kurt
dc.contributor.author Johansson, Åsa
dc.contributor.author Tönjes, Anke
dc.contributor.author Dehghan, Abbas
dc.contributor.author Chouraki, Vincent
dc.contributor.author Holliday, Elizabeth G.
dc.contributor.author Sorice, Rossella
dc.contributor.author Kutalik, Zoltan
dc.contributor.author Lehtimäki, Terho
dc.contributor.author Esko, Tõnu
dc.contributor.author Deshmukh, Harshal
dc.contributor.author Ulivi, Sheila
dc.contributor.author Murgia, Federico
dc.contributor.author Trompet, Stella
dc.contributor.author Imboden, Medea
dc.contributor.author Kollerits, Barbara
dc.contributor.author Pistis, Giorgio
dc.contributor.author Harris, Tamara B.
dc.contributor.author Launer, Lenore J.
dc.contributor.author Aspelund, Thor
dc.contributor.author Eiriksdottir, Gudny
dc.contributor.author Mitchell, Braxton D.
dc.contributor.author Boerwinkle, Eric
dc.contributor.author Schmidt, Helena
dc.contributor.author Cavalieri, Margherita
dc.contributor.author Rao, Madhumathi
dc.contributor.author Demirkan, Ayse
dc.contributor.author Oostra, Ben A.
dc.contributor.author de Andrade, Mariza
dc.contributor.author Ding, Jingzhong
dc.contributor.author Andrews, Jeanette S.
dc.contributor.author Freedman, Barry I.
dc.contributor.author Koenig, Wolfgang
dc.contributor.author Illig, Thomas
dc.contributor.author Döring, Angela
dc.contributor.author Wichmann, H.-Erich
dc.contributor.author Kolcic, Ivana
dc.contributor.author Zemunik, Tatijana
dc.contributor.author Boban, Mladen
dc.contributor.author Minelli, Cosetta
dc.contributor.author Wheeler, Heather E.
dc.contributor.author Igl, Wilmar
dc.contributor.author Zaboli, Ghazal
dc.contributor.author Wild, Sarah H.
dc.contributor.author Wright, Alan F.
dc.contributor.author Campbell, Harry
dc.contributor.author Ellinghaus, David
dc.contributor.author Nöthlings, Ute
dc.contributor.author Jacobs, Gunnar
dc.contributor.author Biffar, Reiner
dc.contributor.author Endlich, Karlhans
dc.contributor.author Ernst, Florian
dc.contributor.author Homuth, Georg
dc.contributor.author Kroemer, Heyo K.
dc.contributor.author Nauck, Matthias
dc.contributor.author Stracke, Sylvia
dc.contributor.author Völker, Uwe
dc.contributor.author Völzke, Henry
dc.contributor.author Kovacs, Peter
dc.contributor.author Stumvoll, Michael
dc.contributor.author Mägi, Reedik
dc.contributor.author Uitterlinden, Andre G.
dc.contributor.author Rivadeneira, Fernando
dc.contributor.author Aulchenko, Yurii S.
dc.contributor.author Polasek, Ozren
dc.contributor.author Hastie, Nick
dc.contributor.author Vitart, Veronique
dc.contributor.author Helmer, Catherine
dc.contributor.author Wang, Jie Jin
dc.contributor.author Ruggiero, Daniela
dc.contributor.author Bergmann, Sven
dc.contributor.author Kähönen, Mika
dc.contributor.author Viikari, Jorma
dc.contributor.author Nikopensius, Tiit
dc.contributor.author Province, Michael
dc.contributor.author Ketkar, Shamika
dc.contributor.author Colhoun, Helen
dc.contributor.author Doney, Alex
dc.contributor.author Robino, Antonietta
dc.contributor.author Giulianini, Franco
dc.contributor.author Krämer, Bernhard K.
dc.contributor.author Portas, Laura
dc.contributor.author Ford, Ian
dc.contributor.author Buckley, Brendan M.
dc.contributor.author Adam, Martin
dc.contributor.author Thun, Gian-Andri
dc.contributor.author Paulweber, Bernhard
dc.contributor.author Haun, Margot
dc.contributor.author Sala, Cinzia
dc.contributor.author Metzger, Marie
dc.contributor.author Mitchell, Paul
dc.contributor.author Ciullo, Marina
dc.contributor.author Kim, Stuart K.
dc.contributor.author Vollenweider, Peter
dc.contributor.author Raitakari, Olli
dc.contributor.author Metspalu, Andres
dc.contributor.author Palmer, Colin
dc.contributor.author Gasparini, Paolo
dc.contributor.author Pirastu, Mario
dc.contributor.author Jukema, J. Wouter
dc.contributor.author Probst-Hensch, Nicole M.
dc.contributor.author Kronenberg, Florian
dc.contributor.author Toniolo, Daniela
dc.contributor.author Gudnason, Vilmundur
dc.contributor.author Shuldiner, Alan R.
dc.contributor.author Coresh, Josef
dc.contributor.author Schmidt, Reinhold
dc.contributor.author Ferrucci, Luigi
dc.contributor.author Siscovick, David S.
dc.contributor.author van Duijn, Cornelia M.
dc.contributor.author Borecki, Ingrid
dc.contributor.author Kardia, Sharon L. R.
dc.contributor.author Liu, Yongmei
dc.contributor.author Rudan, Igor
dc.contributor.author Gyllensten, Ulf
dc.contributor.author Wilson, James F.
dc.contributor.author Franke, Andre
dc.contributor.author Pramstaller, Peter P.
dc.contributor.author Rettig, Rainer
dc.contributor.author Prokopenko, Inga
dc.contributor.author Witteman, Jacqueline C. M.
dc.contributor.author Hayward, Caroline
dc.contributor.author Parsa, Afshin
dc.contributor.author Bochud, Murielle
dc.contributor.author Heid, Iris M.
dc.contributor.author Garnaas, Maija
dc.contributor.author O'Seaghdha, Conall
dc.contributor.author Li, Guo
dc.contributor.author Johnson, Andrew D.
dc.contributor.author Cornelis, Marilyn
dc.contributor.author Chu, Audrey Yu-lei
dc.contributor.author Hu, Frank B.
dc.contributor.author Turner, Stephen T.
dc.contributor.author Hofman, Albert
dc.contributor.author Curhan, Gary Craig
dc.contributor.author Ridker, Paul M.
dc.contributor.author Goessling, Wolfram
dc.contributor.author Chasman, Daniel Ian
dc.contributor.author Kao, W. H. Linda
dc.contributor.author Fox, Caroline
dc.date.accessioned 2012-10-23T15:17:08Z
dc.date.issued 2012
dc.identifier.citation Pattaro, Cristian, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger, Christian Fuchsberger, Matthias Olden, et al. 2012. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8(3): e1002584. en_US
dc.identifier.issn 1553-7390 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9795487
dc.description.abstract Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near \(MPPED2\), \(DDX1\), \(SLC47A1\), \(CDK12\), \(CASP9\), and \(INO80\). Morpholino knockdown of \(mpped2\) and \(casp9\) in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pgen.1002584 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455/pdf/ en_US
dash.license LAA
dc.subject biology en_US
dc.subject genetics en_US
dc.title Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS Genetics en_US
dash.depositing.author O'Seaghdha, Conall
dc.date.available 2012-10-23T15:17:08Z

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