Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
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Pattaro, Cristian |
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Köttgen, Anna |
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Teumer, Alexander |
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Böger, Carsten A. |
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Fuchsberger, Christian |
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Olden, Matthias |
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Chen, Ming-Huei |
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Tin, Adrienne |
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Taliun, Daniel |
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Li, Man |
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Gao, Xiaoyi |
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Gorski, Mathias |
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Yang, Qiong |
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Hundertmark, Claudia |
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Foster, Meredith C. |
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Glazer, Nicole |
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Isaacs, Aaron |
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Liu, Ching-Ti |
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Smith, Albert V. |
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O'Connell, Jeffrey R. |
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Struchalin, Maksim |
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Tanaka, Toshiko |
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Gierman, Hinco J. |
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Feitosa, Mary |
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Hwang, Shih-Jen |
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Atkinson, Elizabeth J. |
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Lohman, Kurt |
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Johansson, Åsa |
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Tönjes, Anke |
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Dehghan, Abbas |
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Chouraki, Vincent |
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Holliday, Elizabeth G. |
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Sorice, Rossella |
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Kutalik, Zoltan |
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Lehtimäki, Terho |
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Esko, Tõnu |
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Deshmukh, Harshal |
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Ulivi, Sheila |
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Murgia, Federico |
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Trompet, Stella |
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Imboden, Medea |
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Kollerits, Barbara |
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Pistis, Giorgio |
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Harris, Tamara B. |
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Launer, Lenore J. |
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Aspelund, Thor |
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Eiriksdottir, Gudny |
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Mitchell, Braxton D. |
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Boerwinkle, Eric |
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Schmidt, Helena |
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Cavalieri, Margherita |
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Rao, Madhumathi |
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Demirkan, Ayse |
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Oostra, Ben A. |
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de Andrade, Mariza |
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Ding, Jingzhong |
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Andrews, Jeanette S. |
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Freedman, Barry I. |
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Koenig, Wolfgang |
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Illig, Thomas |
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Döring, Angela |
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Wichmann, H.-Erich |
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Kolcic, Ivana |
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Zemunik, Tatijana |
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Boban, Mladen |
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Minelli, Cosetta |
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Wheeler, Heather E. |
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Igl, Wilmar |
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Zaboli, Ghazal |
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Wild, Sarah H. |
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Wright, Alan F. |
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Campbell, Harry |
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Ellinghaus, David |
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Nöthlings, Ute |
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Jacobs, Gunnar |
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Biffar, Reiner |
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Endlich, Karlhans |
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Ernst, Florian |
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Homuth, Georg |
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Kroemer, Heyo K. |
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Nauck, Matthias |
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Stracke, Sylvia |
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Völker, Uwe |
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Völzke, Henry |
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Kovacs, Peter |
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Stumvoll, Michael |
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Mägi, Reedik |
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Uitterlinden, Andre G. |
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Rivadeneira, Fernando |
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Aulchenko, Yurii S. |
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Polasek, Ozren |
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Hastie, Nick |
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Vitart, Veronique |
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Helmer, Catherine |
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Wang, Jie Jin |
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Ruggiero, Daniela |
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Bergmann, Sven |
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Kähönen, Mika |
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Viikari, Jorma |
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Nikopensius, Tiit |
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Province, Michael |
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Ketkar, Shamika |
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Colhoun, Helen |
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Doney, Alex |
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Robino, Antonietta |
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Giulianini, Franco |
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Krämer, Bernhard K. |
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Portas, Laura |
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Ford, Ian |
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Buckley, Brendan M. |
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Adam, Martin |
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Thun, Gian-Andri |
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Paulweber, Bernhard |
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Haun, Margot |
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Sala, Cinzia |
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Metzger, Marie |
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Mitchell, Paul |
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Ciullo, Marina |
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Kim, Stuart K. |
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Vollenweider, Peter |
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Raitakari, Olli |
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Metspalu, Andres |
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Palmer, Colin |
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Gasparini, Paolo |
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Pirastu, Mario |
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Jukema, J. Wouter |
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Probst-Hensch, Nicole M. |
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Kronenberg, Florian |
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Toniolo, Daniela |
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Gudnason, Vilmundur |
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Shuldiner, Alan R. |
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Coresh, Josef |
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Schmidt, Reinhold |
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Ferrucci, Luigi |
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Siscovick, David S. |
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van Duijn, Cornelia M. |
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Borecki, Ingrid |
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Kardia, Sharon L. R. |
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Liu, Yongmei |
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Rudan, Igor |
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Gyllensten, Ulf |
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Wilson, James F. |
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Franke, Andre |
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Pramstaller, Peter P. |
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Rettig, Rainer |
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Prokopenko, Inga |
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Witteman, Jacqueline C. M. |
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Hayward, Caroline |
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Parsa, Afshin |
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Bochud, Murielle |
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Heid, Iris M. |
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Garnaas, Maija |
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O'Seaghdha, Conall
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Li, Guo |
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Johnson, Andrew D. |
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Cornelis, Marilyn
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Chu, Audrey Yu-lei
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Hu, Frank B.
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Turner, Stephen T. |
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Hofman, Albert
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Curhan, Gary Craig
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Ridker, Paul M.
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Goessling, Wolfram
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Chasman, Daniel Ian
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Kao, W. H. Linda |
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Fox, Caroline
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| dc.date.accessioned |
2012-10-23T15:17:08Z |
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| dc.date.issued |
2012 |
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| dc.identifier.citation |
Pattaro, Cristian, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger, Christian Fuchsberger, Matthias Olden, et al. 2012. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8(3): e1002584. |
en_US |
| dc.identifier.issn |
1553-7390 |
en_US |
| dc.identifier.uri |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:9795487 |
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| dc.description.abstract |
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near \(MPPED2\), \(DDX1\), \(SLC47A1\), \(CDK12\), \(CASP9\), and \(INO80\). Morpholino knockdown of \(mpped2\) and \(casp9\) in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. |
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| dc.language.iso |
en_US |
en_US |
| dc.publisher |
Public Library of Science |
en_US |
| dc.relation.isversionof |
doi:10.1371/journal.pgen.1002584 |
en_US |
| dc.relation.hasversion |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455/pdf/ |
en_US |
| dash.license |
LAA |
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| dc.subject |
biology |
en_US |
| dc.subject |
genetics |
en_US |
| dc.title |
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
en_US |
| dc.type |
Journal Article |
en_US |
| dc.description.version |
Version of Record |
en_US |
| dc.relation.journal |
PLoS Genetics |
en_US |
| dash.depositing.author |
O'Seaghdha, Conall
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| dc.date.available |
2012-10-23T15:17:08Z |
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