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Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

dc.contributor.authorPattaro, Cristian
dc.contributor.authorKöttgen, Anna
dc.contributor.authorTeumer, Alexander
dc.contributor.authorBöger, Carsten A.
dc.contributor.authorFuchsberger, Christian
dc.contributor.authorOlden, Matthias
dc.contributor.authorChen, Ming-Huei
dc.contributor.authorTin, Adrienne
dc.contributor.authorTaliun, Daniel
dc.contributor.authorLi, Man
dc.contributor.authorGao, Xiaoyi
dc.contributor.authorGorski, Mathias
dc.contributor.authorYang, Qiong
dc.contributor.authorHundertmark, Claudia
dc.contributor.authorFoster, Meredith C.
dc.contributor.authorGlazer, Nicole
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorLiu, Ching-Ti
dc.contributor.authorSmith, Albert V.
dc.contributor.authorO'Connell, Jeffrey R.
dc.contributor.authorStruchalin, Maksim
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorGierman, Hinco J.
dc.contributor.authorFeitosa, Mary
dc.contributor.authorHwang, Shih-Jen
dc.contributor.authorAtkinson, Elizabeth J.
dc.contributor.authorLohman, Kurt
dc.contributor.authorJohansson, Åsa
dc.contributor.authorTönjes, Anke
dc.contributor.authorDehghan, Abbas
dc.contributor.authorChouraki, Vincent
dc.contributor.authorHolliday, Elizabeth G.
dc.contributor.authorSorice, Rossella
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorEsko, Tõnu
dc.contributor.authorDeshmukh, Harshal
dc.contributor.authorUlivi, Sheila
dc.contributor.authorMurgia, Federico
dc.contributor.authorTrompet, Stella
dc.contributor.authorImboden, Medea
dc.contributor.authorKollerits, Barbara
dc.contributor.authorPistis, Giorgio
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorAspelund, Thor
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorMitchell, Braxton D.
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorSchmidt, Helena
dc.contributor.authorCavalieri, Margherita
dc.contributor.authorRao, Madhumathi
dc.contributor.authorDemirkan, Ayse
dc.contributor.authorOostra, Ben A.
dc.contributor.authorde Andrade, Mariza
dc.contributor.authorDing, Jingzhong
dc.contributor.authorAndrews, Jeanette S.
dc.contributor.authorFreedman, Barry I.
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorIllig, Thomas
dc.contributor.authorDöring, Angela
dc.contributor.authorWichmann, H.-Erich
dc.contributor.authorKolcic, Ivana
dc.contributor.authorZemunik, Tatijana
dc.contributor.authorBoban, Mladen
dc.contributor.authorMinelli, Cosetta
dc.contributor.authorWheeler, Heather E.
dc.contributor.authorIgl, Wilmar
dc.contributor.authorZaboli, Ghazal
dc.contributor.authorWild, Sarah H.
dc.contributor.authorWright, Alan F.
dc.contributor.authorCampbell, Harry
dc.contributor.authorEllinghaus, David
dc.contributor.authorNöthlings, Ute
dc.contributor.authorJacobs, Gunnar
dc.contributor.authorBiffar, Reiner
dc.contributor.authorEndlich, Karlhans
dc.contributor.authorErnst, Florian
dc.contributor.authorHomuth, Georg
dc.contributor.authorKroemer, Heyo K.
dc.contributor.authorNauck, Matthias
dc.contributor.authorStracke, Sylvia
dc.contributor.authorVölker, Uwe
dc.contributor.authorVölzke, Henry
dc.contributor.authorKovacs, Peter
dc.contributor.authorStumvoll, Michael
dc.contributor.authorMägi, Reedik
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorAulchenko, Yurii S.
dc.contributor.authorPolasek, Ozren
dc.contributor.authorHastie, Nick
dc.contributor.authorVitart, Veronique
dc.contributor.authorHelmer, Catherine
dc.contributor.authorWang, Jie Jin
dc.contributor.authorRuggiero, Daniela
dc.contributor.authorBergmann, Sven
dc.contributor.authorKähönen, Mika
dc.contributor.authorViikari, Jorma
dc.contributor.authorNikopensius, Tiit
dc.contributor.authorProvince, Michael
dc.contributor.authorKetkar, Shamika
dc.contributor.authorColhoun, Helen
dc.contributor.authorDoney, Alex
dc.contributor.authorRobino, Antonietta
dc.contributor.authorGiulianini, Franco
dc.contributor.authorKrämer, Bernhard K.
dc.contributor.authorPortas, Laura
dc.contributor.authorFord, Ian
dc.contributor.authorBuckley, Brendan M.
dc.contributor.authorAdam, Martin
dc.contributor.authorThun, Gian-Andri
dc.contributor.authorPaulweber, Bernhard
dc.contributor.authorHaun, Margot
dc.contributor.authorSala, Cinzia
dc.contributor.authorMetzger, Marie
dc.contributor.authorMitchell, Paul
dc.contributor.authorCiullo, Marina
dc.contributor.authorKim, Stuart K.
dc.contributor.authorVollenweider, Peter
dc.contributor.authorRaitakari, Olli
dc.contributor.authorMetspalu, Andres
dc.contributor.authorPalmer, Colin
dc.contributor.authorGasparini, Paolo
dc.contributor.authorPirastu, Mario
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorProbst-Hensch, Nicole M.
dc.contributor.authorKronenberg, Florian
dc.contributor.authorToniolo, Daniela
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorShuldiner, Alan R.
dc.contributor.authorCoresh, Josef
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorSiscovick, David S.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorBorecki, Ingrid
dc.contributor.authorKardia, Sharon L. R.
dc.contributor.authorLiu, Yongmei
dc.contributor.authorRudan, Igor
dc.contributor.authorGyllensten, Ulf
dc.contributor.authorWilson, James F.
dc.contributor.authorFranke, Andre
dc.contributor.authorPramstaller, Peter P.
dc.contributor.authorRettig, Rainer
dc.contributor.authorProkopenko, Inga
dc.contributor.authorWitteman, Jacqueline C. M.
dc.contributor.authorHayward, Caroline
dc.contributor.authorParsa, Afshin
dc.contributor.authorBochud, Murielle
dc.contributor.authorHeid, Iris M.
dc.contributor.authorGarnaas, Maija
dc.contributor.authorO'Seaghdha, Conall
dc.contributor.authorLi, Guo
dc.contributor.authorJohnson, Andrew D.
dc.contributor.authorCornelis, Marilyn
dc.contributor.authorChu, Audrey Yu-lei
dc.contributor.authorHu, Frank B.
dc.contributor.authorTurner, Stephen T.
dc.contributor.authorHofman, Albert
dc.contributor.authorCurhan, Gary Craig
dc.contributor.authorRidker, Paul M.
dc.contributor.authorGoessling, Wolfram
dc.contributor.authorChasman, Daniel Ian
dc.contributor.authorKao, W. H. Linda
dc.contributor.authorFox, Caroline
dc.date.accessioned2012-10-23T15:17:08Z
dc.date.issued2012
dc.identifier.citationPattaro, Cristian, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger, Christian Fuchsberger, Matthias Olden, et al. 2012. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8(3): e1002584.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9795487
dc.description.abstractChronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near \(MPPED2\), \(DDX1\), \(SLC47A1\), \(CDK12\), \(CASP9\), and \(INO80\). Morpholino knockdown of \(mpped2\) and \(casp9\) in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1002584en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455/pdf/en_US
dash.licenseLAA
dc.subjectbiologyen_US
dc.subjectgeneticsen_US
dc.titleGenome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Functionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorO'Seaghdha, Conall
dc.date.available2012-10-23T15:17:08Z
dc.identifier.doi10.1371/journal.pgen.1002584*
dash.authorsorderedfalse
dash.contributor.affiliatedO'Seaghdha, Conall
dash.contributor.affiliatedCornelis, Marilyn
dash.contributor.affiliatedGoessling, Wolfram
dash.contributor.affiliatedFox, Caroline
dash.contributor.affiliatedCurhan, Gary
dash.contributor.affiliatedChu, Audrey Yu-lei
dash.contributor.affiliatedChasman, Daniel
dash.contributor.affiliatedRidker, Paul
dash.contributor.affiliatedHofman, Albert
dash.contributor.affiliatedHu, Frank
dc.identifier.orcid0000-0003-1249-4522


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