Cardiovascular Inflammation in Healthy Women: Multilevel Associations with State-Level Prosperity, Productivity and Income Inequality

DSpace/Manakin Repository

Cardiovascular Inflammation in Healthy Women: Multilevel Associations with State-Level Prosperity, Productivity and Income Inequality

Show simple item record

dc.contributor.author Ommerborn, Mark J
dc.contributor.author Huisingh, Carrie E
dc.contributor.author Clark, Cheryl
dc.contributor.author Ridker, Paul M.
dc.contributor.author Coull, Brent Andrew
dc.contributor.author Buring, Julie Elizabeth
dc.contributor.author Berkman, Lisa Faye
dc.date.accessioned 2012-10-26T16:34:05Z
dc.date.issued 2012
dc.identifier.citation Clark, Cheryl R., Paul M. Ridker, Mark J. Ommerborn, Carrie E. Huisingh, Brent Coull, Julie E. Buring, and Lisa F. Berkman. 2012. Cardiovascular inflammation in healthy women: Multilevel associations with state-level prosperity, productivity and income inequality. BMC Public Health 12: 211. en_US
dc.identifier.issn 1471-2458 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9809466
dc.description.abstract Background: Cardiovascular inflammation is a key contributor to the development of atherosclerosis and the prediction of cardiovascular events among healthy women. An emerging literature suggests biomarkers of inflammation vary by geography of residence at the state-level, and are associated with individual-level socioeconomic status. Associations between cardiovascular inflammation and state-level socioeconomic conditions have not been evaluated. The study objective is to estimate whether there are independent associations between state-level socioeconomic conditions and individual-level biomarkers of inflammation, in excess of individual-level income and clinical covariates among healthy women. Methods: The authors examined cross-sectional multilevel associations among state-level socioeconomic conditions, individual-level income, and biomarkers of inflammation among women (n = 26,029) in the Women's Health Study, a nation-wide cohort of healthy women free of cardiovascular diseases at enrollment. High sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1) and fibrinogen were measured between 1993 and 1996. Biomarker levels were examined among women within quartiles of state-level socioeconomic conditions and within categories of individual-level income. Results: The authors found that favorable state-level socioeconomic conditions were correlated with lower hsCRP, in excess of individual-level income (e.g. state-level real per capital gross domestic product fixed effect standardized Βeta coefficient [Std B] -0.03, 95% CI -0.05, -0.004). Individual-level income was more closely associated with sICAM-1 (Std B -0.04, 95% CI -0.06, -0.03) and fibrinogen (Std B -0.05, 95% CI -0.06, -0.03) than state-level conditions. Conclusions: We found associations between state-level socioeconomic conditions and hsCRP among healthy women. Personal household income was more closely associated with sICAM-1 and fibrinogen than state-level socioeconomic conditions. Additional research should examine these associations in other cohorts, and investigate what more-advantaged states do differently than less-advantaged states that may influence levels of cardiovascular inflammation among healthy women. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.relation.isversionof doi:10.1186/1471-2458-12-211 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323890/pdf/ en_US
dash.license LAA
dc.subject c-reactive protein en_US
dc.subject geography en_US
dc.subject income en_US
dc.subject inflammation en_US
dc.subject multilevel analysis en_US
dc.subject poverty en_US
dc.subject socioeconomic factors en_US
dc.subject women’s health en_US
dc.title Cardiovascular Inflammation in Healthy Women: Multilevel Associations with State-Level Prosperity, Productivity and Income Inequality en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal BMC Public Health en_US
dash.depositing.author Clark, Cheryl
dc.date.available 2012-10-26T16:34:05Z

Files in this item

Files Size Format View
3323890.pdf 385.4Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters