In-vivo Vomeronasal Stimulation Reveals Sensory Encoding of Conspecific and Allospecific Cues by the Mouse Accessory Olfactory Bulb

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In-vivo Vomeronasal Stimulation Reveals Sensory Encoding of Conspecific and Allospecific Cues by the Mouse Accessory Olfactory Bulb

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Title: In-vivo Vomeronasal Stimulation Reveals Sensory Encoding of Conspecific and Allospecific Cues by the Mouse Accessory Olfactory Bulb
Author: Dulac, Catherine; Ben-Shaul, Yoram; Katz, Lawrence C.; Mooney, Richard

Note: Order does not necessarily reflect citation order of authors.

Citation: Ben-Shaul, Yoram, Larry C. Katz, Richard Mooney, and Catherine Dulac. 2010. In-vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb. Proceedings of the National Academy of Science 107(11): 5172-5177.
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Abstract: The rodent vomeronasal system plays a critical role in mediating pheromone-evoked social and sexual behaviors. Recent studies of the anatomical and molecular architecture of the vomeronasal organ (VNO) and of its synaptic target, the accessory olfactory bulb (AOB), have suggested that unique features underlie vomeronasal sensory processing. However, the neuronal representation of pheromonal information leading to specific behavioral and endocrine responses has remained largely unexplored due to the experimental difficulty of precise stimulus delivery to the VNO. To determine the basic rules of information processing in the vomeronasal system, we developed a unique preparation that allows controlled and repeated stimulus delivery to the VNO and combined this approach with multisite recordings of neuronal activity in the AOB. We found that urine, a well-characterized pheromone source in mammals, as well as saliva, activates AOB neurons in a manner that reliably encodes the donor animal’s sexual and genetic status. We also identified a significant fraction of AOB neurons that respond robustly and selectively to predator cues, suggesting an expanded role for the vomeronasal system in both conspecific and interspecific recognition. Further analysis reveals that mixed stimuli from distinct sources evoke synergistic responses in AOB neurons, thereby supporting the notion of integrative processing of chemosensory information.
Published Version: doi:10.1073/pnas.0915147107
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:9887624

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  • FAS Scholarly Articles [6463]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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