In-vivo Vomeronasal Stimulation Reveals Sensory Encoding of Conspecific and Allospecific Cues by the Mouse Accessory Olfactory Bulb

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In-vivo Vomeronasal Stimulation Reveals Sensory Encoding of Conspecific and Allospecific Cues by the Mouse Accessory Olfactory Bulb

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dc.contributor.author Dulac, Catherine
dc.contributor.author Ben-Shaul, Yoram
dc.contributor.author Katz, Lawrence C.
dc.contributor.author Mooney, Richard
dc.date.accessioned 2012-11-08T17:59:49Z
dc.date.issued 2010
dc.identifier.citation Ben-Shaul, Yoram, Larry C. Katz, Richard Mooney, and Catherine Dulac. 2010. In-vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb. Proceedings of the National Academy of Science 107(11): 5172-5177. en_US
dc.identifier.issn 1091-6490 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9887624
dc.description.abstract The rodent vomeronasal system plays a critical role in mediating pheromone-evoked social and sexual behaviors. Recent studies of the anatomical and molecular architecture of the vomeronasal organ (VNO) and of its synaptic target, the accessory olfactory bulb (AOB), have suggested that unique features underlie vomeronasal sensory processing. However, the neuronal representation of pheromonal information leading to specific behavioral and endocrine responses has remained largely unexplored due to the experimental difficulty of precise stimulus delivery to the VNO. To determine the basic rules of information processing in the vomeronasal system, we developed a unique preparation that allows controlled and repeated stimulus delivery to the VNO and combined this approach with multisite recordings of neuronal activity in the AOB. We found that urine, a well-characterized pheromone source in mammals, as well as saliva, activates AOB neurons in a manner that reliably encodes the donor animal’s sexual and genetic status. We also identified a significant fraction of AOB neurons that respond robustly and selectively to predator cues, suggesting an expanded role for the vomeronasal system in both conspecific and interspecific recognition. Further analysis reveals that mixed stimuli from distinct sources evoke synergistic responses in AOB neurons, thereby supporting the notion of integrative processing of chemosensory information. en_US
dc.description.sponsorship Molecular and Cellular Biology en_US
dc.language.iso en_US en_US
dc.publisher National Academy of Sciences en_US
dc.relation.isversionof doi:10.1073/pnas.0915147107 en_US
dash.license LAA
dc.subject pheromones en_US
dc.subject sensory processing en_US
dc.subject vomeronasal en_US
dc.subject accessory olfactory bulb en_US
dc.subject mouse en_US
dc.title In-vivo Vomeronasal Stimulation Reveals Sensory Encoding of Conspecific and Allospecific Cues by the Mouse Accessory Olfactory Bulb en_US
dc.type Journal Article en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Proceedings of the National Academy of Science en_US
dash.depositing.author Dulac, Catherine
dash.waiver 2010-01-25
dc.date.available 2012-11-08T17:59:49Z

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  • FAS Scholarly Articles [5137]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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