Molecular Organization of Vomeronasal Chemoreception

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Molecular Organization of Vomeronasal Chemoreception

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dc.contributor.author Isogai, Yoh
dc.contributor.author Si, Sheng
dc.contributor.author Pont-Lezica, Lorena
dc.contributor.author Tan, Taralyn Marie
dc.contributor.author Kapoor, Vikrant
dc.contributor.author Murthy, Venkatesh N.
dc.contributor.author Dulac, Catherine
dc.date.accessioned 2012-11-12T21:03:58Z
dc.date.issued 2011
dc.identifier.citation Isogai, Yoh, Sheng Si, Lorena Pont-Lezica, Taralyn Marie Tan, Vikrant Kapoor, Venkatesh N. Murthy, and Catherine Dulac. 2011. Molecular organization of vomeronasal chemoreception. Nature 478(7368): 241-245. en_US
dc.identifier.issn 0028-0836 en_US
dc.identifier.issn 1476-4687 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9888893
dc.description.abstract The vomeronasal organ (VNO) has a key role in mediating the social and defensive responses of many terrestrial vertebrates to species- and sex-specific chemosignals. More than 250 putative pheromone receptors have been identified in the mouse VNO, but the nature of the signals detected by individual VNO receptors has not yet been elucidated. To gain insight into the molecular logic of VNO detection leading to mating, aggression or defensive responses, we sought to uncover the response profiles of individual vomeronasal receptors to a wide range of animal cues. Here we describe the repertoire of behaviourally and physiologically relevant stimuli detected by a large number of individual vomeronasal receptors in mice, and define a global map of vomeronasal signal detection. We demonstrate that the two classes (V1R and V2R) of vomeronasal receptors use fundamentally different strategies to encode chemosensory information, and that distinct receptor subfamilies have evolved towards the specific recognition of certain animal groups or chemical structures. The association of large subsets of vomeronasal receptors with cognate, ethologically and physiologically relevant stimuli establishes the molecular foundation of vomeronasal information coding, and opens new avenues for further investigating the neural mechanisms underlying behaviour specificity. en_US
dc.description.sponsorship Molecular and Cellular Biology en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof doi:10.1038/nature10437 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192931/ en_US
dash.license OAP
dc.subject animal behavior en_US
dc.subject molecular biology en_US
dc.subject neuroscience en_US
dc.subject genomics en_US
dc.subject genetics en_US
dc.title Molecular Organization of Vomeronasal Chemoreception en_US
dc.type Journal Article en_US
dc.description.version Author's Original en_US
dc.relation.journal Nature en_US
dash.depositing.author Dulac, Catherine
dc.date.available 2012-11-12T21:03:58Z

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  • FAS Scholarly Articles [7374]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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