Specific Mesenchymal/Epithelial Induction of Olfactory Receptor, Vomeronasal, and Gonadotropin-Releasing Hormone (GnRH) Neurons

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Specific Mesenchymal/Epithelial Induction of Olfactory Receptor, Vomeronasal, and Gonadotropin-Releasing Hormone (GnRH) Neurons

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dc.contributor.author Dulac, Catherine
dc.contributor.author Pevny, L.
dc.contributor.author Rawson, N. E.
dc.contributor.author Lischka, F. W.
dc.contributor.author Yee, K. K.
dc.contributor.author Peters, A. Z.
dc.contributor.author Tucker, E. S.
dc.contributor.author Meechan, D. W.
dc.contributor.author Zirlinger, M.
dc.contributor.author Maynard, T. M.
dc.contributor.author Burd, G. B.
dc.contributor.author LaMantia, A.-S.
dc.date.accessioned 2012-11-12T21:10:12Z
dc.date.issued 2010
dc.identifier.citation Rawson, N. E., F. W. Lischka, K. K. Yee, A. Z. Peters, E. S. Tucker, D. W. Meechan, M. Zirlinger, et al. 2010. Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons. Developmental Dynamics 239(6): 1723-1738. en_US
dc.identifier.issn 1058-8388 en_US
dc.identifier.issn 1097-0177 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9888894
dc.description.abstract We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin-releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E-mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE-specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons. en_US
dc.description.sponsorship Molecular and Cellular Biology en_US
dc.language.iso en_US en_US
dc.publisher Wiley-Blackwell en_US
dc.relation.isversionof doi:10.1002/dvdy.22315 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pubmed/20503368 en_US
dash.license OAP
dc.subject induction en_US
dc.subject olfactory en_US
dc.subject neurogenesis en_US
dc.subject limb bud en_US
dc.title Specific Mesenchymal/Epithelial Induction of Olfactory Receptor, Vomeronasal, and Gonadotropin-Releasing Hormone (GnRH) Neurons en_US
dc.type Journal Article en_US
dc.description.version Author's Original en_US
dc.relation.journal Developmental Dynamics en_US
dash.depositing.author Dulac, Catherine
dc.date.available 2012-11-12T21:10:12Z

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  • FAS Scholarly Articles [7374]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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